# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325268 | A | AUC (infinity) in Wistar Han rat at 1 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4321873 | organism-based format | Scientific Literature | |
2. | ALA4325269 | A | Half life in Wistar Han rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4321873 | organism-based format | Scientific Literature | |
3. | ALA4325272 | A | Volume of distribution at steady state in Wistar Han rat at 1 mg/kg, iv or 1 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4321873 | organism-based format | Scientific Literature | |
4. | ALA4325273 | P | Kinetic solubility of the compound in pH 7.4 phosphate buffered saline measured after 1 hr by CLND method | 4 | ALA4321873 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4325274 | A | Passive apparent permeability in MDCK2-MDR1 cells at pH 7.4 in presence of P-gp inhibitor | Canis lupus familiaris | 4 | ALA4321873 | cell-based format | Scientific Literature | |
6. | ALA4479329 | B | Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in presence of biotin-labeled PIP3 by HTRF assay | Homo sapiens | 9 | ALA4477235 | single protein format | Scientific Literature | |
7. | ALA4479333 | B | Selectivity ratio of IC50 for PI3Kalpha (unknown origin) to IC50 for PI3Kdelta (unknown origin) | Homo sapiens | 9 | ALA4477235 | assay format | Scientific Literature | |
8. | ALA4479334 | B | Selectivity ratio of IC50 for PI3Kbeta (unknown origin) to IC50 for PI3Kdelta (unknown origin) | Homo sapiens | 9 | ALA4477235 | assay format | Scientific Literature | |
9. | ALA4479335 | B | Selectivity ratio of IC50 for PI3Kgamma (unknown origin) to IC50 for PI3Kdelta (unknown origin) | Homo sapiens | 9 | ALA4477235 | assay format | Scientific Literature | |
10. | ALA4479336 | B | Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assay | Homo sapiens | 4 | ALA4477235 | single protein format | Scientific Literature | |
11. | ALA4479337 | A | Clearance in rat liver microsomes at 0.5 uM measured up to 30 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4477235 | microsome format | Scientific Literature | |
12. | ALA4479338 | A | Clearance in mouse liver microsomes at 0.5 uM measured up to 30 mins by LC-MS/MS analysis | Mus musculus | 4 | ALA4477235 | microsome format | Scientific Literature | |
13. | ALA4479339 | A | Clearance in human liver microsomes at 0.5 uM measured up to 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4477235 | microsome format | Scientific Literature | |
14. | ALA4479340 | A | AUC(infinity) in Sprague-Dawley rat at 3 mg/kg, po measured up to 7 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4477235 | organism-based format | Scientific Literature | |
15. | ALA4479341 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4477235 | organism-based format | Scientific Literature | |
16. | ALA4479342 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv measured up to 7 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4477235 | organism-based format | Scientific Literature | |
17. | ALA4479343 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg measured up to 7 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4477235 | organism-based format | Scientific Literature | |
18. | ALA4479344 | A | Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, po or 1 mg/kg, iv measured up to 7 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4477235 | organism-based format | Scientific Literature | |
19. | ALA4479345 | A | Binding affinity to human serum albumin by HPLC analysis | Homo sapiens | 4 | ALA4477235 | single protein format | Scientific Literature | |
20. | ALA4479346 | P | Kinetic solubility in phosphate buffered saline at pH 7.4 after 1 hr by chemiluminescent nitrogen detection method | 6 | ALA4477235 | small-molecule physicochemical format | Scientific Literature |