# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4342646 | B | Inhibition of BACE1 (unknown origin) incubated for 120 mins using APP swedish mutant as substrate by FRET assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
2. | ALA4342647 | A | Inhibition of BACE2 (unknown origin) incubated for 450 mins using APP swedish mutant as substrate by FRET assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
3. | ALA4342648 | F | In vivo inhibition of BACE1 in Beagle dog assessed as reduction in amyloidbeta (1 to 42 residues) at 0.16 mg/kg, po measured at 8 hrs post dose relative to baseline | Canis lupus familiaris | 2 | organism-based format | Scientific Literature | ||
4. | ALA4342649 | F | In vivo inhibition of BACE1 in Beagle dog assessed as reduction in amyloidbeta (1 to 42 residues) at 0.31 mg/kg, po measured at 8 hrs post dose relative to baseline | Canis lupus familiaris | 2 | organism-based format | Scientific Literature | ||
5. | ALA4342650 | F | In vivo inhibition of BACE1 in Beagle dog assessed as reduction in amyloidbeta (1 to 42 residues) at 1.25 mg/kg, po measured at 8 hrs post dose relative to baseline | Canis lupus familiaris | 2 | organism-based format | Scientific Literature | ||
6. | ALA4342651 | B | Inhibition of BACE1 in human SK-N-BE(2) cells expressing human APP695 assessed as reduction in amyloidbeta (1 to 42 residues) level incubated for 18 hrs by sandwich ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature |