# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4430888 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as inhibition of DEM-induced lipid peroxidation at 0.1 to 1 uM pre-incubated for 16 hrs followed by DEM addition for 120 mins by C11-BODIPY581/591 probe based flow cytometry relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
2. | ALA4430890 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as suppression of DEM-induced intracellular ROS levels at 100 nM pre-incubated for 16 hrs followed by DEM addition for 80 mins by DCFH-DA probe based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
3. | ALA4430892 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 100 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
4. | ALA4430893 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 1000 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
5. | ALA4430894 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 2500 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
6. | ALA4430895 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
7. | ALA4430896 | A | Effect on mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 incubated for 16 hrs by TMRM dye based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
8. | ALA4430897 | F | Increase in total intracellular ATP levels in FRDA patient derived lymphocyte GM15850 grown in galactose medium at 1 uM after 48 hrs by luciferin-luciferase reaction based bioluminescence assay relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
9. | ALA4430898 | F | Increase in total intracellular ATP levels in FRDA patient derived lymphocyte GM15850 grown in galactose medium at 5 uM after 48 hrs by luciferin-luciferase reaction based bioluminescence assay relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
10. | ALA4430899 | F | Increase in total intracellular ATP levels in FRDA patient derived lymphocyte GM15850 grown in galactose medium at 20 uM after 48 hrs by luciferin-luciferase reaction based bioluminescence assay relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
11. | ALA4430901 | F | Cytoprotective activity against DEM induced oxidative stress in FRDA patient derived lymphocyte GM15850 assessed as cell viability at 0.5 uM pre-incubated for 16 hrs followed by DEM addition for 6 hrs by calcein AM/EthD-1 staining based flow cytometry | Homo sapiens | 8 | ALA4428118 | cell-based format | Scientific Literature | |
12. | ALA4430902 | F | Cytoprotective activity against DEM induced oxidative stress in FRDA patient derived lymphocyte GM15850 assessed as cell viability at 0.1 uM pre-incubated for 16 hrs followed by DEM addition for 6 hrs by calcein AM/EthD-1 staining based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
13. | ALA4430903 | A | Stability in bovine liver microsomes assessed as drug recovery at 25 uM after 30 mins in presence of beta-NADPH by HPLC analysis | Bos taurus | 9 | ALA4428118 | microsome format | Scientific Literature |