| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4400310 | B | Inhibition of recombinant human N-terminal GST-tagged MET (956 to 1390 residues) cytoplasmic domain expressed in baculovirus expression system using Srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 8 | ALA4396963 | assay format | Scientific Literature | |
| 2. | ALA4400312 | B | Inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) cytoplasmic domain L1196M mutant expressed in baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 8 | ALA4396963 | assay format | Scientific Literature | |
| 3. | ALA4400313 | B | Inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) cytoplasmic domain expressed in baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 8 | ALA4396963 | assay format | Scientific Literature | |
| 4. | ALA4400314 | F | Antiproliferative activity against human NCI-H2228 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 36 | ALA4396963 | cell-based format | Scientific Literature | |
| 5. | ALA4400315 | F | Antiproliferative activity against human KARPAS299 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 36 | ALA4396963 | cell-based format | Scientific Literature | |
| 6. | ALA4400316 | F | Antiproliferative activity against human HCC78 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 36 | ALA4396963 | cell-based format | Scientific Literature | |
| 7. | ALA4400317 | F | Antiproliferative activity against human A549 cells harbouring EGFR G1202R mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 36 | ALA4396963 | cell-based format | Scientific Literature | |
| 8. | ALA4400318 | F | Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 36 | ALA4396963 | cell-based format | Scientific Literature | |
| 9. | ALA4400319 | F | Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 36 | ALA4396963 | cell-based format | Scientific Literature | |
| 10. | ALA4400320 | F | Potency index, ratio of IC50 of ceritinib to IC50 of compound for antiproliferative activity against human A549 cells harbouring EGFR G1202R mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 1 | ALA4396963 | cell-based format | Scientific Literature | |
| 11. | ALA4400321 | B | Inhibition of recombinant human N-terminal GST-tagged ROS (1883 to 2347 residues) cytoplasmic domain expressed in baculovirus expression system using IRS1 as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 8 | ALA4396963 | assay format | Scientific Literature | |
| 12. | ALA4400322 | B | Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system using Srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 8 | ALA4396963 | assay format | Scientific Literature | |
| 13. | ALA4400323 | B | Inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) cytoplasmic domain G1202R mutant using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 8 | ALA4396963 | single protein format | Scientific Literature | |
| 14. | ALA4400324 | B | Potency index, ratio of IC50 of ceritinib to IC50 of compound for inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) cytoplasmic domain expressed in baculovirus expression system L1196M mutant using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4396963 | assay format | Scientific Literature | |
| 15. | ALA4400325 | B | Potency index, ratio of IC50 of ceritinib to IC50 of compound for inhibition of recombinant human N-terminal GST-tagged ROS (1883 to 2347 residues) cytoplasmic domain expressed in baculovirus expression system using IRS1 as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4396963 | assay format | Scientific Literature | |
| 16. | ALA4400326 | B | Potency index, ratio of IC50 of ceritinib to IC50 of compound for inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) cytoplasmic domain G1202R mutant expressed in baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4396963 | assay format | Scientific Literature | |
| 17. | ALA4400327 | F | Induction of apoptosis in human NCI-H2228 cells assessed as increase in cell membrane damage incubated for 48 hrs by Hoechst 33258 staining based fluorescence microscopy | Homo sapiens | 1 | ALA4396963 | cell-based format | Scientific Literature | |
| 18. | ALA4400328 | F | Induction of apoptosis in human NCI-H2228 cells assessed as increase in nuclei damage incubated for 48 hrs by Hoechst 33258 staining based fluorescence microscopy | Homo sapiens | 1 | ALA4396963 | cell-based format | Scientific Literature | |
| 19. | ALA4400331 | F | Induction of apoptosis in human NCI-H2228 cells assessed as increase in nuclear shrinkage incubated for 48 hrs by AO/EB staining based fluorescence microscopy | Homo sapiens | 1 | ALA4396963 | cell-based format | Scientific Literature | |
| 20. | ALA4400332 | F | Induction of apoptosis in human NCI-H2228 cells assessed as increase in nuclear fragmentation incubated for 48 hrs by AO/EB staining based fluorescence microscopy | Homo sapiens | 1 | ALA4396963 | cell-based format | Scientific Literature |
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