# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4418123 | B | Inhibition of TMPRSS4 serine protease domain (Val 205 to Leu 437 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) at 100 uM using Bac-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride substrate and measured for 5 mins at 5 mins intervals by fluorescence based assay relative to control | Homo sapiens | 66 | assay format | Patent Bioactivity Data | ||
2. | ALA4418124 | B | Inhibition of TMPRSS4 serine protease domain (Val 205 to Leu 437 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) at 30 uM using Bac-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride substrate and measured for 5 mins at 5 mins intervals by fluorescence based assay relative to control | Homo sapiens | 66 | assay format | Patent Bioactivity Data | ||
3. | ALA4418125 | B | Inhibition of TMPRSS4 serine protease domain (Val 205 to Leu 437 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM using Bac-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride substrate and measured for 5 mins at 5 mins intervals by fluorescence based assay relative to control | Homo sapiens | 66 | assay format | Patent Bioactivity Data | ||
4. | ALA4418126 | B | Inhibition of TMPRSS4 serine protease domain (Val 205 to Leu 437 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using Bac-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride substrate and measured for 5 mins at 5 mins intervals by fluorescence based assay relative to control | Homo sapiens | 66 | assay format | Patent Bioactivity Data | ||
5. | ALA4418543 | B | Inhibition of TMPRSS4 serine protease domain (Val205 to Leu437 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) at 100 uM using Z-Phe-Arg7-amido-4-methylcoumarin hydrochloride substrate measured at 5 mins interval for 150 mins by fluorescence based assay relative to control | Homo sapiens | 75 | assay format | Patent Bioactivity Data | ||
6. | ALA4418544 | B | Inhibition of TMPRSS4 serine protease domain (Val205 to Leu437 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) at 30 uM using Z-Phe-Arg7-amido-4-methylcoumarin hydrochloride substrate measured at 5 mins interval for 150 mins by fluorescence based assay relative to control | Homo sapiens | 75 | assay format | Patent Bioactivity Data | ||
7. | ALA4418545 | B | Inhibition of TMPRSS4 serine protease domain (Val205 to Leu437 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM using Z-Phe-Arg7-amido-4-methylcoumarin hydrochloride substrate measured at 5 mins interval for 150 mins by fluorescence based assay relative to control | Homo sapiens | 75 | assay format | Patent Bioactivity Data | ||
8. | ALA4821030 | F | Cytotoxicity against human SNB-19 cells assessed as cell viability at 30 uM relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
9. | ALA4821031 | B | Inhibition of NS-1in Zika virus | Zika virus | 69 | assay format | Scientific Literature | ||
10. | ALA4821032 | B | Inhibition of envelope protein in Zika virus | Zika virus | 69 | assay format | Scientific Literature | ||
11. | ALA4821033 | A | Metabolic stability in rat liver microsomes | Rattus norvegicus | 69 | microsome format | Scientific Literature | ||
12. | ALA4821034 | A | Permeability of compound by PAMPA assay | 69 | assay format | Scientific Literature | |||
13. | ALA4821035 | P | Solubility of the compound | 69 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA4821036 | F | Antiviral activity against Zika virus infected in SNB-19 cells assessed as reduction in viral titer | Homo sapiens | 9 | cell-based format | Scientific Literature |