| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4380426 | A | Inhibition of CYP2E1 in human liver microsomes at 20 uM using chlorzoxazone as substrate incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 5 | ALA4376865 | microsome format | Scientific Literature | |
| 2. | ALA4380427 | A | Inhibition of CYP2D6 in human liver microsomes at 20 uM using dextromethorphan as substrate incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 5 | ALA4376865 | microsome format | Scientific Literature | |
| 3. | ALA4380428 | F | Antagonist activity at human EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux at 10 uM preincubated for 15 mins followed by addition of PGE2 by calcium flux assay relative to control | Homo sapiens | 52 | ALA4376865 | cell-based format | Scientific Literature | |
| 4. | ALA4380429 | F | Antagonist activity at human EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins followed by addition of PGE2 by calcium flux assay | Homo sapiens | 52 | ALA4376865 | cell-based format | Scientific Literature | |
| 5. | ALA4380430 | F | Antagonist activity at mouse EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins followed by addition of PGE2 by calcium flux assay | Mus musculus | 13 | ALA4376865 | cell-based format | Scientific Literature | |
| 6. | ALA4380431 | F | Antagonist activity at human EP1 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins followed by addition of PGE2 by calcium flux assay | Homo sapiens | 13 | ALA4376865 | cell-based format | Scientific Literature | |
| 7. | ALA4380432 | F | Antagonist activity at human EP2 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins followed by addition of PGE2 by calcium flux assay | Homo sapiens | 13 | ALA4376865 | cell-based format | Scientific Literature | |
| 8. | ALA4380433 | F | Antagonist activity at human EP3 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins followed by addition of PGE2 by calcium flux assay | Homo sapiens | 13 | ALA4376865 | cell-based format | Scientific Literature | |
| 9. | ALA4380434 | A | Metabolic stability in human liver microsomes assessed as half life at 10 uM incubated for 1 hr | Homo sapiens | 10 | ALA4376865 | microsome format | Scientific Literature | |
| 10. | ALA4380435 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 10 uM incubated for 1 hr | Homo sapiens | 10 | ALA4376865 | microsome format | Scientific Literature | |
| 11. | ALA4380436 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 10 uM incubated for 1 hr | Homo sapiens | 10 | ALA4376865 | microsome format | Scientific Literature | |
| 12. | ALA4380437 | A | Metabolic stability in CD1 mouse liver microsomes assessed as half life at 10 uM incubated for 1 hr | Mus musculus | 10 | ALA4376865 | microsome format | Scientific Literature | |
| 13. | ALA4380438 | A | Metabolic stability in CD1 mouse liver microsomes assessed as intrinsic clearance at 10 uM incubated for 1 hr | Mus musculus | 10 | ALA4376865 | microsome format | Scientific Literature | |
| 14. | ALA4380439 | A | Metabolic stability in CD1 mouse liver microsomes assessed as compound remaining at 10 uM incubated for 1 hr | Mus musculus | 10 | ALA4376865 | microsome format | Scientific Literature | |
| 15. | ALA4380440 | A | Inhibition of CYP1A2 in human liver microsomes at 20 uM using phenacetin as substrate incubated for 30 mins by HPLC analysis relative to control | Homo sapiens | 5 | ALA4376865 | microsome format | Scientific Literature | |
| 16. | ALA4380441 | A | Inhibition of CYP2B6 in human liver microsomes at 20 uM incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 5 | ALA4376865 | microsome format | Scientific Literature | |
| 17. | ALA4380442 | A | Inhibition of CYP2C9 in human liver microsomes at 20 uM using tolbutamide as substrate incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 5 | ALA4376865 | microsome format | Scientific Literature | |
| 18. | ALA4380443 | A | Inhibition of CYP3A4 in human liver microsomes at 20 uM using testosterone as substrate incubated for 60 mins by HPLC analysis | Homo sapiens | 5 | ALA4376865 | microsome format | Scientific Literature | |
| 19. | ALA4380444 | A | Cmax in BALB/c mouse at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4376865 | organism-based format | Scientific Literature | |
| 20. | ALA4380445 | A | AUC (0 to infinity) in BALB/c mouse at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4376865 | organism-based format | Scientific Literature |
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