# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4422180 | B | Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by TAMRA fluorescence-based assay | Homo sapiens | 20 | ALA4421727 | single protein format | Patent Bioactivity Data | |
2. | ALA4422181 | B | Inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by PAGE-based cleavage assay | Homo sapiens | 6 | ALA4421727 | single protein format | Patent Bioactivity Data | |
3. | ALA4422182 | B | Inhibition of NEIL1 (unknown origin) assessed as remaining enzyme activity at 50 uM using Sp/Gh substrate incubated for 40 mins by TAMRA fluorescence-based assay | Homo sapiens | 20 | ALA4421727 | single protein format | Patent Bioactivity Data | |
4. | ALA4422183 | B | Inhibition of NTH1 (unknown origin) assessed as remaining enzyme activity at 50 uM incubated for 40 mins by TAMRA fluorescence-based assay | Homo sapiens | 20 | ALA4421727 | single protein format | Patent Bioactivity Data | |
5. | ALA4422184 | B | Inhibition of Escherichia coli FPG assessed as remaining enzyme activity at 50 uM using 8-oxo-Gua substrate incubated for 10 mins by TAMRA fluorescence-based assay | Escherichia coli | 20 | ALA4421727 | single protein format | Patent Bioactivity Data | |
6. | ALA4422186 | B | Inhibition of human OGG1 assessed as reduction in AP lyase activity using AP-containing substrate | Homo sapiens | 7 | ALA4421727 | single protein format | Patent Bioactivity Data | |
7. | ALA4422187 | B | Inhibition of human OGG1 assessed as reduction in free 8-oxo-Gua release using gamma-irradiated calf thymus DNA substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 7 | ALA4421727 | single protein format | Patent Bioactivity Data | |
8. | ALA4422188 | B | Inhibition of human OGG1 assessed as reduction in free Inhibition of human OGG1 assessed as reduction in free FapyGua release using gamma-irradiated calf thymus DNA substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 7 | ALA4421727 | single protein format | Patent Bioactivity Data | |
9. | ALA4422189 | B | Inhibition of NEIL1 (unknown origin) using Sp/Gh substrate incubated for 40 mins by TAMRA fluorescence-based assay | Homo sapiens | 6 | ALA4421727 | single protein format | Patent Bioactivity Data | |
10. | ALA4422190 | B | Inhibition of NTH1 (unknown origin) incubated for 40 mins by TAMRA fluorescence-based assay | Homo sapiens | 6 | ALA4421727 | single protein format | Patent Bioactivity Data | |
11. | ALA4422191 | B | Inhibition of Escherichia coli FPG using 8-oxo-Gua substrate incubated for 10 mins by TAMRA fluorescence-based assay | Escherichia coli | 6 | ALA4421727 | single protein format | Patent Bioactivity Data | |
12. | ALA4422192 | B | Selectivity index, ratio of IC50 for inhibition of NEIL1 (unknown origin) using Sp/Gh substrate incubated for 40 mins by TAMRA fluorescence-based assay to IC50 for inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by TAMRA fluorescence-based assay | Homo sapiens | 6 | ALA4421727 | assay format | Patent Bioactivity Data | |
13. | ALA4422193 | B | Selectivity index, ratio of IC50 for inhibition of NTH1 (unknown origin) incubated for 40 mins by TAMRA fluorescence-based assay to IC50 for inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by TAMRA fluorescence-based assay | Homo sapiens | 6 | ALA4421727 | assay format | Patent Bioactivity Data | |
14. | ALA4422194 | B | Selectivity index, ratio of IC50 for inhibition of Escherichia coli FPG using 8-oxo-Gua substrate incubated for 10 mins by TAMRA fluorescence-based assay to IC50 for inhibition of human OGG1 incubated for 30 mins using 8-oxo-Gua-containing substrate by TAMRA fluorescence-based assay | 6 | ALA4421727 | assay format | Patent Bioactivity Data | ||
15. | ALA4422195 | B | Inhibition of NEIL1 (unknown origin) assessed as effect on DNA lesions per 10'6 DNA bases using FapyAde substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 5 | ALA4421727 | single protein format | Patent Bioactivity Data | |
16. | ALA4422196 | B | Inhibition of NEIL1 (unknown origin) assessed as effect on DNA lesions per 10'6 DNA bases using FapyGua substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 5 | ALA4421727 | single protein format | Patent Bioactivity Data | |
17. | ALA4422197 | B | Inhibition of NEIL1 (unknown origin) assessed as effect on DNA lesions per 10'6 DNA bases using 5-OH-5-MeHyd substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 5 | ALA4421727 | single protein format | Patent Bioactivity Data | |
18. | ALA4422198 | B | Inhibition of NTH1 (unknown origin) assessed as effect on DNA lesions per 10'6 DNA bases using FapyAde substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 5 | ALA4421727 | single protein format | Patent Bioactivity Data | |
19. | ALA4422199 | B | Inhibition of NTH1 (unknown origin) assessed as effect on DNA lesions per 10'6 DNA bases using FapyGua substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 5 | ALA4421727 | single protein format | Patent Bioactivity Data | |
20. | ALA4422200 | B | Inhibition of NTH1 (unknown origin) assessed as effect on DNA lesions per 10'6 DNA bases using 5-OH-5-MeHyd substrate incubated for 1 hr by GC-MS/MS assay | Homo sapiens | 5 | ALA4421727 | single protein format | Patent Bioactivity Data |