| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4389075 | A | Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv relative to hepatic blood flow | Rattus norvegicus | 1 | ALA4387741 | organism-based format | Scientific Literature | |
| 2. | ALA4389076 | A | Clearance in human liver microsomes relative to hepatic blood flow | Homo sapiens | 2 | ALA4387741 | microsome format | Scientific Literature | |
| 3. | ALA4389077 | B | Inhibition of human phosphorylated ABL1 E255K mutant (S229 to K512 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 4. | ALA4389078 | B | Reversible inhibition of recombinant full-length N-terminal 6-His-tagged human BTK expressed in baculovirus infected Sf21 insect cells using fluorescent-labeled polyGAT peptide as substrate incubated for 30 mins by TR-FRET assay | Homo sapiens | 33 | ALA4387741 | cell-based format | Scientific Literature | |
| 5. | ALA4389547 | B | Binding affinity to wild-type human partial length ITK (R335 to L620 residues) expressed in bacterial expression system by Kinomescan method | Homo sapiens | 2 | ALA4387741 | assay format | Scientific Literature | |
| 6. | ALA4389548 | B | Binding affinity to wild-type human partial length TEC (L341 to D620 residues) expressed in bacterial expression system by Kinomescan method | Homo sapiens | 2 | ALA4387741 | assay format | Scientific Literature | |
| 7. | ALA4389549 | B | Binding affinity to wild-type human partial length TXK tyrosine kinase (L238 to W527 residues) expressed in bacterial expression system by Kinomescan method | Homo sapiens | 2 | ALA4387741 | assay format | Scientific Literature | |
| 8. | ALA4389550 | B | Binding affinity to wild-type human full length BMX non-receptor tyrosine kinase (M1 to H675 residues) expressed in bacterial expression system by Kinomescan method | Homo sapiens | 2 | ALA4387741 | assay format | Scientific Literature | |
| 9. | ALA4389552 | B | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4387741 | single protein format | Scientific Literature | |
| 10. | ALA4389553 | B | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA4387741 | single protein format | Scientific Literature | |
| 11. | ALA4389554 | B | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 2 | ALA4387741 | single protein format | Scientific Literature | |
| 12. | ALA4389555 | B | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | ALA4387741 | single protein format | Scientific Literature | |
| 13. | ALA4389556 | B | Inhibition of BTK in human PBMC assessed as reduction in CD69 expression | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 14. | ALA4389557 | B | Inhibition of human wild-type AAK1 (G25 to L333 residues) expressed in bacterial expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 15. | ALA4389558 | B | Inhibition of human non-phosphorylated ABL1 F317I mutant (S229 to K512 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 16. | ALA4389559 | B | Inhibition of human phosphorylated ABL1 F317I mutant (S229 to K512 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 17. | ALA4389560 | B | Inhibition of human non-phosphorylated ABL1 F317L mutant (S229 to K512 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 18. | ALA4389561 | B | Inhibition of human phosphorylated ABL1 F317L mutant (S229 to K512 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 19. | ALA4389562 | B | Inhibition of human non-phosphorylated ABL1 H396P mutant (S229 to K512 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature | |
| 20. | ALA4389563 | B | Inhibition of human phosphorylated ABL1 H396P mutant (S229 to K512 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4387741 | assay format | Scientific Literature |
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