# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4378183 | B | Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 34 | assay format | Scientific Literature | ||
2. | ALA4378184 | B | Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulation and measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 32 | single protein format | Scientific Literature | ||
3. | ALA4378185 | P | Octanol/Sodium phosphate buffer partition coefficient, log D of compound at pH 7.4 at 1 mg incubated for overnight under shaking condition by LC-MS/MS analysis | 31 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4378186 | A | Intrinsic clearance in human hepatocytes at 1 uM assessed as per million cells after 2 to 60 mins by LC-MS/MS analysis | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
5. | ALA4378198 | A | GSH reactivity in human liver microsomes assessed as GSH adduct formation in presence of NADPH by QTOF-MS analysis | Homo sapiens | 18 | microsome format | Scientific Literature | ||
6. | ALA4378199 | A | Displacement of [3H]-GABA/[3]-muscimol from GABA gated chloride channel in Sprague-Dawley rat cortical synoptic membranes by liquid scintillation analysis | Rattus norvegicus | 18 | assay format | Scientific Literature |