| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4418717 | B | Substrate activity at LRAT in bovine RPE microsomes at 1 mM incubated for 1 hr at 37 degC by HPLC analysis relative to corresponding primary alcohols | Bos taurus | 36 | assay format | Patent Bioactivity Data | ||
| 2. | ALA4418718 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as effect on thickness of outer nuclear layer at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by SDOCT and ERG analysis | Mus musculus | 12 | organism-based format | Patent Bioactivity Data | ||
| 3. | ALA4418719 | B | Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production pre-incubated at room temperature for 5 mins before all-trans-retinol addition and further incubated for 15 mins to 2 hrs in presence of CRALBP by normal phase HPLC analysis | Bos taurus | 36 | assay format | Patent Bioactivity Data | ||
| 4. | ALA4418720 | T | Toxicity in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse model of intense light-induced retinal degeneration at 1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by SDOCT and ERG analysis | Mus musculus | 12 | organism-based format | Patent Bioactivity Data | ||
| 5. | ALA4418723 | F | Protective effect against intense light-induced retinal degeneration in wild type mouse assessed as rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.2 mg pretreated with compound followed by exposure to light illumination 2 hrs after compound dosing (Rvb = 85 +/- 5%) by HPLC analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 6. | ALA4418724 | F | Protective effect against intense light-induced retinal degeneration in wild type mouse assessed as rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.2 mg pretreated with compound followed by exposure to light illumination 24 hrs after compound dosing (Rvb = 85 +/- 5%) by HPLC analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 7. | ALA4418725 | F | Protective effect against intense light-induced retinal degeneration in wild type mouse assessed as rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.2 mg pretreated with compound followed by exposure to light illumination 3 days after compound dosing (Rvb = 85 +/- 5%) by HPLC analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 8. | ALA4418726 | F | Protective effect against intense light-induced retinal degeneration in wild type mouse assessed as rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.2 mg pretreated with compound followed by exposure to light illumination 7 days after compound dosing (Rvb = 85 +/- 5%) by HPLC analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 9. | ALA4418727 | F | Protective effect against intense light-induced retinal degeneration in wild type mouse assessed as rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.5 mg pretreated with compound followed by exposure to light illumination 7 days after compound dosing (Rvb = 85 +/- 5%) by HPLC analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 10. | ALA4418728 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by HPLC analysis relative to control | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 11. | ALA4418729 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.2 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by HPLC analysis relative to control | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 12. | ALA4418730 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visual chromophore recovery by measuring 11-cis- retinal level in eye at 0.5 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr by HPLC analysis relative to control | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 13. | ALA4418731 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse at 0.1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 3 days by OCT analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 14. | ALA4418732 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as ONL thickness at 0.5 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 3 days by OCT analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 15. | ALA4418733 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as ONL thickness at 0.2 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 3 days by OCT analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 16. | ALA4418734 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visual chromophore recovery by measuring 11-cis- retinal level per eye at 0.2 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 7 days by HPLC analysis (Rvb = 452 +/-43 pmol/eye) | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 17. | ALA4418735 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse assessed as inhibition of rate of visual chromophore recovery by measuring 11-cis- retinal level per eye at 0.1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 7 days by HPLC analysis (Rvb = 301+/- 8 pmol/eye) | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 18. | ALA4418736 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse at 0.2 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 3 days by ERG analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 19. | ALA4418737 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse at 0.5 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 3 days by ERG analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
| 20. | ALA4418738 | F | Protective effect against intense light-induced retinal degeneration in 4 weeks old Abca4(-/-)/Rdh8 (-/-) mouse at 0.1 mg dosed via gavage under dark for 24 hrs before exposure to 10000 lux bright light for 1 hr followed by exposure to dark for 3 days by ERG analysis | Mus musculus | 1 | organism-based format | Patent Bioactivity Data |
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