| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4376618 | Binding | Binding affinity to biotinylated N-terminal His6-tagged recombinant KRAS G12C mutant (unknown origin) by BLI method | Homo sapiens | 5 | ALA4373743 | single protein format | Scientific Literature | |
| 2. | ALA4376619 | Binding | Binding affinity to biotinylated N-terminal His6-tagged recombinant KRAS G12C mutant (unknown origin) assessed as association constant by BLI method | Homo sapiens | 5 | ALA4373743 | single protein format | Scientific Literature | |
| 3. | ALA4376620 | Binding | Binding affinity to biotinylated N-terminal His6-tagged recombinant KRAS G12C mutant (unknown origin) assessed as dissociation constant by BLI method | Homo sapiens | 5 | ALA4373743 | single protein format | Scientific Literature | |
| 4. | ALA4376621 | Functional | Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant incubated for 24 hrs by MTT assay | Homo sapiens | 2 | ALA4373743 | cell-based format | Scientific Literature | |
| 5. | ALA4376622 | Functional | Antiproliferative activity against human A549 cells harboring KRAS G12S mutant at 0.37 to 10 uM incubated for 24 hrs by MTT assay | Homo sapiens | 2 | ALA4373743 | cell-based format | Scientific Literature | |
| 6. | ALA4376623 | Binding | Inhibition of mant-GDP bound N-terminal His6-tagged recombinant KRAS G12C mutant (unknown origin) by fluorescence based assay | Homo sapiens | 2 | ALA4373743 | single protein format | Scientific Literature | |
| 7. | ALA4376624 | Functional | Induction of cell cycle arrest in human NCI-H358 cells harboring KRAS G12C mutant assessed as accumulation at G2/M phase at 10 to 40 uM incubated for 24 hrs by PI staining based flow cytometric analysis (Rvb = 11.08%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 8. | ALA4376625 | Functional | Induction of cell cycle arrest in human A549 cells harboring KRAS G12S mutant assessed as accumulation at G2/M phase at 10 to 40 uM incubated for 24 hrs by PI staining based flow cytometric analysis | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 9. | ALA4376626 | Functional | Induction of cell cycle arrest in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cyclin B1 protein expression at 40 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 10. | ALA4376627 | Functional | Induction of cell cycle arrest in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in CDK1 protein expression at 40 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 11. | ALA4376628 | Functional | Induction of cell cycle arrest in human A549 cells harboring KRAS G12S mutant assessed as as reduction in cyclin B1 protein expression at 40 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 12. | ALA4376629 | Functional | Induction of cell cycle arrest in human A549 cells harboring KRAS G12S mutant assessed as reduction in CDK1 protein expression at 40 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 13. | ALA4376630 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as viable cells at 2.5 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 67.2%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 14. | ALA4376631 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as early apoptotic cells at 2.5 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 4.34%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 15. | ALA4376632 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as late apoptotic cells at 2.5 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 28.2%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 16. | ALA4376633 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as necrotic cells at 2.5 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 0.28%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 17. | ALA4376634 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as viable cells at 10 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 67.2%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 18. | ALA4376635 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as early apoptotic cells at 10 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 4.34%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 19. | ALA4376636 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as late apoptotic cells at 10 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 28.2%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature | |
| 20. | ALA4376637 | Functional | Induction of apoptosis in human NCI-H358 cells harboring KRAS G12C mutant assessed as necrotic cells at 10 uM incubated for 24 hrs by Annexin V-FITC/PI staining based flow cytometric analysis (Rvb = 0.28%) | Homo sapiens | 1 | ALA4373743 | cell-based format | Scientific Literature |
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