# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4421916 | B | Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as reduction in geranylgeranylation of RhoA incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay relative to control | Rattus norvegicus | 87 | ALA4421722 | assay format | Patent Bioactivity Data | |
2. | ALA4421917 | F | Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 27 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
3. | ALA4421920 | F | Antiproliferative activity against human Jurkat cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 33 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
4. | ALA4421921 | F | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay | Homo sapiens | 8 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
5. | ALA4421922 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 4 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
6. | ALA4421923 | F | Antiproliferative activity against human BT474 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 7 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
7. | ALA4421924 | A | Antiproliferative activity against human MCF10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 6 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
8. | ALA4421925 | F | Antiproliferative activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 8 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
9. | ALA4421926 | F | Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay | Homo sapiens | 7 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
10. | ALA4421927 | F | Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 7 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
11. | ALA4421928 | F | Antiproliferative activity against human Capan2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 8 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
12. | ALA4421929 | F | Antiproliferative activity against human CFPAC-1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 8 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
13. | ALA4421931 | B | Competitive inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as reduction in geranylgeranylation of RhoA incubated for 30 mins in presence of varying level of [3H]GGPP and fixed RhoA levels by scintillation counting assay relative to control | Rattus norvegicus | 4 | ALA4421722 | assay format | Patent Bioactivity Data | |
14. | ALA4421944 | B | Inhibition of geranylgeranyltransferase type I in HEK293 cells expressing Myc-HA-tagged Rheb-WT assessed as effect on unprenylated Rap1 accumulation at 2.5 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 2 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
15. | ALA4421945 | B | Inhibition of FTase in HEK293 cells assessed as reduction in H-ras farnesylation at 2.5 to 10 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
16. | ALA4421947 | B | Inhibition of RabGGTase in HEK293 cells assessed as reduction in geranylgeranylation of Rab5b protein at 5 to 10 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
17. | ALA4421949 | B | Inhibition of RabGGTase (unknown origin) at 100000 nM using YPTI as substrate protein and [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 1 | ALA4421722 | protein complex format | Patent Bioactivity Data | |
18. | ALA4421950 | B | Inhibition of rat recombinant FTase alpha/beta expressed in Escherichia coli at 100000 nM using K-Ras4B as a substrate as and [3H]farnesyl pyrophosphate incubated for 30 mins by scintillation counting assay | Rattus norvegicus | 1 | ALA4421722 | assay format | Patent Bioactivity Data | |
19. | ALA4421951 | F | Antiproliferative activity against human SEMK2 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay | Homo sapiens | 2 | ALA4421722 | cell-based format | Patent Bioactivity Data | |
20. | ALA4421952 | F | Antiproliferative activity against human HPAC cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay | Homo sapiens | 2 | ALA4421722 | cell-based format | Patent Bioactivity Data |