# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4394191 | ADME | Substrate activity at Staphylococcus saprophyticus nitroreductase expressed in Escherichia coli assessed as retention time in the presence of NADPH at 100 uM by HPLC analysis (0 to 5 mins at 20 % ACN, 15 to 22 min at 80% ACN, 27-32 AT 20% ACN) | Staphylococcus saprophyticus | 16 | ALA4393661 | assay format | Scientific Literature | |
2. | ALA4394197 | ADME | Cytotoxicity in human PC3 cells assessed as reduction in cell viability at 180 nM measured after 48 hrs by SRB assay | Homo sapiens | 16 | ALA4393661 | cell-based format | Scientific Literature | |
3. | ALA4394198 | ADME | Cytotoxicity against human PC3 cells assessed as reduction in cell viability measured after 48 hrs in presence of Staphylococcus saprophyticus nitroreductase and NADH by SRB assay | Homo sapiens | 16 | ALA4393661 | cell-based format | Scientific Literature | |
4. | ALA4394199 | ADME | Cytotoxicity against human Hep3B cells assessed as cell viability at 9 to 150 uM measured after 48 hrs by MTT assay relative to control | Homo sapiens | 23 | ALA4393661 | cell-based format | Scientific Literature | |
5. | ALA4394200 | ADME | Cytotoxicity against human HUVEC cells assessed as cell viability at 9 to 150 uM measured after 48 hrs by MTT assay relative to control | Homo sapiens | 23 | ALA4393661 | cell-based format | Scientific Literature | |
6. | ALA4394201 | ADME | Cytotoxicity against human PC3 cells assessed as cell viability at 9 to 150 uM measured after 48 hrs by MTT assay relative to control | Homo sapiens | 23 | ALA4393661 | cell-based format | Scientific Literature | |
7. | ALA4394240 | Physicochemical | Solubility of the compound in 15% DMSO | 11 | ALA4393661 | small-molecule physicochemical format | Scientific Literature |