# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4353986 | B | Inhibition of human recombinant C-terminal His/FLAG-tagged HDAC1 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by fluorescence based assay | Homo sapiens | 11 | ALA4351000 | single protein format | Scientific Literature | |
2. | ALA4353987 | B | Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by fluorescence based assay | Homo sapiens | 11 | ALA4351000 | single protein format | Scientific Literature | |
3. | ALA4353988 | B | Inhibition of human recombinant C-terminal His-tagged HDAC3/NCOR2 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by fluorescence based assay | Homo sapiens | 11 | ALA4351000 | protein complex format | Scientific Literature | |
4. | ALA4353989 | B | Selectivity ratio of IC50 for human recombinant C-terminal His-tagged HDAC3/NCOR2 to IC50 for human recombinant C-terminal His/FLAG-tagged HDAC1 | Homo sapiens | 2 | ALA4351000 | assay format | Scientific Literature | |
5. | ALA4353990 | B | Selectivity ratio of IC50 for human recombinant C-terminal His-tagged HDAC3/NCOR2 to IC50 for human recombinant C-terminal FLAG-tagged HDAC2 | Homo sapiens | 2 | ALA4351000 | assay format | Scientific Literature | |
6. | ALA4353991 | A | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 1 to 5 uM incubated for 24 hrs by MTS assay | Mus musculus | 6 | ALA4351000 | cell-based format | Scientific Literature | |
7. | ALA4354007 | B | Inhibition of HDAC1/2 in LPS/IFNgamma-stimulated mouse RAW264.7 cells assessed as upregulation of TNF-alpha gene expression at pretreated for 16 hrs followed by LPS stimulation and measured after 4 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA4351000 | cell-based format | Scientific Literature | |
8. | ALA4354008 | B | Inhibition of HDAC1/2 in LPS/IFNgamma-stimulated mouse RAW264.7 cells assessed as upregulation of IL-6 gene expression at pretreated for 16 hrs followed by LPS stimulation and measured after 4 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA4351000 | cell-based format | Scientific Literature | |
9. | ALA4354009 | B | Inhibition of HDAC1/2 in LPS/IFNgamma-stimulated mouse RAW264.7 cells assessed as upregulation of iNOS gene expression at pretreated for 16 hrs followed by LPS stimulation and measured after 4 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA4351000 | cell-based format | Scientific Literature | |
10. | ALA4354010 | B | Inhibition of HDAC1/2 in LPS/IFNgamma-stimulated mouse RAW264.7 cells assessed as upregulation of IL-10 gene expression at pretreated for 16 hrs followed by LPS stimulation and measured after 4 hrs by RT-qPCR analysis | Mus musculus | 1 | ALA4351000 | cell-based format | Scientific Literature |