| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4370818 | B | Inhibition of Leucyl-tRNA synthetase-mediated mTORC1 signaling activation in human HEK293 cells assessed as reduction in leucine-induced S6K phosphorylation preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA4370819 | B | Inhibition of Leucyl-tRNA synthetase-mediated mTORC1 signaling activation in human HEK293 cells assessed as reduction in leucine-induced S6K phosphorylation at 200 uM preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis | Homo sapiens | 48 | cell-based format | Scientific Literature | ||
| 3. | ALA4370820 | B | Inhibition of mTORC2 signaling in human HEK293 cells assessed as reduction in leucine-induced AKT phosphorylation at 200 uM preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 4. | ALA4370821 | F | Effect on leucine-induced AKT levels in human HEK293 cells at 200 uM preincubated for 50 mins followed by leucine-stimulation and measured after 10 mins by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA4370822 | F | Antiproliferative activity against human A549 cells after 72 hrs by SRB assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 6. | ALA4370823 | F | Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 7. | ALA4370824 | F | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 8. | ALA4370825 | F | Antiproliferative activity against human SKHEP1 cells after 72 hrs by SRB assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 9. | ALA4370826 | F | Antiproliferative activity against human SNU638 cells after 72 hrs by SRB assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 10. | ALA4370827 | A | Antiproliferative activity against human MRC5 cells after 72 hrs by SRB assay | Homo sapiens | 9 | cell-based format | Scientific Literature |
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