# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4433438 | B | Inhibition of human H3R expressed in methylhistamine-induced human H3-bla U2OS cells incubated for 30 mins by beta-lactamase complementation technology | Homo sapiens | 18 | ALA4433203 | cell-based format | Scientific Literature | |
2. | ALA4433439 | B | Inhibition of mouse brain AChE using acetylthiocholine iodide as substrate measured after 30 mins by Ellman's method | Mus musculus | 18 | ALA4433203 | assay format | Scientific Literature | |
3. | ALA4433440 | B | Inhibition of mouse plasma BuChE using S-butyrylacetylthiocholine iodide as substrate at 10 uM measured after 30 mins by Ellman's method relative to control | Mus musculus | 16 | ALA4433203 | single protein format | Scientific Literature | |
4. | ALA4433441 | B | Inhibition of human H3R expressed in methylhistamine-induced human H3-bla U2OS cells at 10 uM incubated for 30 mins by beta-lactamase complementation technology relative to control | Homo sapiens | 14 | ALA4433203 | cell-based format | Scientific Literature | |
5. | ALA4433442 | B | Inhibition of mouse brain AChE at 10 uM using acetylthiocholine iodide as substrate measured after 30 mins by Ellman's method | Mus musculus | 14 | ALA4433203 | assay format | Scientific Literature | |
6. | ALA4433443 | F | Antioxidant activity assessed as AAPH radical scavenging activity preincubated for 15 mins with fluorescein before AAPH addition and recorded every 2 mins for 160 mins by ORAC-FL assay | 16 | ALA4433203 | assay format | Scientific Literature | ||
7. | ALA4433444 | A | Cytotoxicity in human SH-SY5Y cells assessed as reduction in cell viability after 72 hrs incubation by MTT assay | Homo sapiens | 4 | ALA4433203 | cell-based format | Scientific Literature | |
8. | ALA4433445 | F | Antialzheimer activity in ICR mouse model of scopolamine-induced cognitive deficit assessed as scopolamine-induced latency time at 10 to 30 mg/kg, po treated for 1 hr followed by scopolamine challenge for 30 mins by step-down passive avoidance test (Rvb = 5 secs) | Mus musculus | 1 | ALA4433203 | organism-based format | Scientific Literature | |
9. | ALA4433446 | T | Selectivity index, ratio of CC50 for human SH-SY5Y cells to IC50 for inhibition of human H3R expressed in methylhistamine-induced human H3-bla U2OS cells | 2 | ALA4433203 | cell-based format | Scientific Literature | ||
10. | ALA4433447 | T | Selectivity index, ratio of CC50 for human SH-SY5Y cells to IC50 for inhibition of mouse brain AChE | 2 | ALA4433203 | assay format | Scientific Literature | ||
11. | ALA4433448 | T | Selectivity index, ratio of CC50 for human SH-SY5Y cells IC50 for mouse plasma BuChE | 2 | ALA4433203 | assay format | Scientific Literature | ||
12. | ALA4433449 | F | Neuroprotective activity against copper-induced cytotoxicity in human SH-SY5Y cells expressing APP Swedish mutant assessed as increase in cell viability at 10 uM pre-incubated for 2 hrs followed by copper addition and measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4433203 | cell-based format | Scientific Literature | |
13. | ALA4433450 | A | Cytotoxicity activity in mouse BV2 cells assessed as reduction in cell viability up to 100 uM measured after 72 hrs incubation by MTT assay | Mus musculus | 1 | ALA4433203 | cell-based format | Scientific Literature | |
14. | ALA4433451 | F | Antialzheimer activity in ICR mouse model of scopolamine-induced cognitive deficit assessed as prolongation of scopolamine-induced latency at 10 to 30 mg/kg, po treated for 1 hr followed by scopolamine challenge for 30 mins by step-down passive avoidance test | Mus musculus | 1 | ALA4433203 | organism-based format | Scientific Literature | |
15. | ALA4433452 | F | Antiinflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced IL-6 production at 10 uM pretreated for 1 hr followed by LPS challenge and measured after 24 hrs by ELISA assay | Mus musculus | 2 | ALA4433203 | cell-based format | Scientific Literature | |
16. | ALA4433453 | F | Antiinflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced TNF-alpha production at 10 uM pretreated for 1 hr followed by LPS challenge and measured after 24 hrs by ELISA assay | Mus musculus | 2 | ALA4433203 | cell-based format | Scientific Literature | |
17. | ALA4433454 | T | Acute toxicity ICR mouse assessed as mortality at 0 to 1000 mg/kg, po measured up to 14 days | Mus musculus | 1 | ALA4433203 | organism-based format | Scientific Literature | |
18. | ALA4433455 | T | Acute toxicity ICR mouse assessed as induction of abnormal behavior at 0 to 1000 mg/kg, po measured up to 14 days | Mus musculus | 1 | ALA4433203 | organism-based format | Scientific Literature | |
19. | ALA4433456 | T | Acute toxicity ICR mouse assessed as effect on drinking behavior at 0 to 1000 mg/kg, po measured up to 14 days | Mus musculus | 1 | ALA4433203 | organism-based format | Scientific Literature | |
20. | ALA4433457 | T | Acute toxicity ICR mouse assessed as effect on eating behavior at 0 to 1000 mg/kg, po measured up to 14 days | Mus musculus | 1 | ALA4433203 | organism-based format | Scientific Literature |