# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4381946 | B | Inhibition of recombinant human IDO1 using L-tryptophan as substrate incubated under dark conditions measured after 60 mins by fluorescence microplate reader assay | Homo sapiens | 57 | ALA4376897 | single protein format | Scientific Literature | |
2. | ALA4381947 | B | Binding affinity to recombinant human IDO1 assessed as induction of shift in Soret peak at 2 mM by UV-vis absorption spectroscopy (Rvb = 403 nm) | Homo sapiens | 1 | ALA4376897 | single protein format | Scientific Literature | |
3. | ALA4381948 | B | Binding affinity to recombinant human IDO1 assessed as equilibrium dissociation constant by SPR assay | Homo sapiens | 1 | ALA4376897 | single protein format | Scientific Literature | |
4. | ALA4381949 | B | Binding affinity to recombinant human IDO1 assessed as kinetic dissociation constant by SPR assay | Homo sapiens | 1 | ALA4376897 | single protein format | Scientific Literature | |
5. | ALA4381950 | B | Binding affinity to recombinant human IDO1 by SPR assay | Homo sapiens | 1 | ALA4376897 | single protein format | Scientific Literature | |
6. | ALA4381951 | F | Antitumor activity against wild type mouse B16F10 cells xenografted in C57BL/6 mouse assessed as tumor volume by measuring T/C ratio at 150 mg/kg, iv administered once every 2 days for 3 weeks and measured after 21 days relative to control | Mus musculus | 1 | ALA4376897 | organism-based format | Scientific Literature | |
7. | ALA4381952 | F | Antitumor activity against wild type mouse B16F10 cells xenografted in C57BL/6 mouse assessed as reduction in tumor volume at 100 to 150 mg/kg, iv administered once every 2 days for 3 weeks and measured after 21 days relative to control | Mus musculus | 1 | ALA4376897 | organism-based format | Scientific Literature | |
8. | ALA4381954 | T | Toxicity in C57BL/6 mouse xenografted with wild type mouse B16/F10 cells assessed as increase in body weight at 100 to 150 mg/kg, iv administered once every 2 days for 3 weeks and measured after 21 days | Mus musculus | 1 | ALA4376897 | organism-based format | Scientific Literature | |
9. | ALA4381955 | F | Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by MTT assay | Homo sapiens | 57 | ALA4376897 | cell-based format | Scientific Literature | |
10. | ALA4381956 | F | Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by MTT assay | Homo sapiens | 57 | ALA4376897 | cell-based format | Scientific Literature | |
11. | ALA4381957 | F | Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay | Homo sapiens | 57 | ALA4376897 | cell-based format | Scientific Literature | |
12. | ALA4381958 | F | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition after 48 hrs by MTT assay | Homo sapiens | 57 | ALA4376897 | cell-based format | Scientific Literature | |
13. | ALA4381959 | F | Antitumor activity against human HepG2 cells xenografted in BALB/c nude mouse assessed as tumor growth suppression at 10 mg/kg, iv administered once every 3 days for 21 consecutive days and measured after 21 days by digital caliper method relative to control | Homo sapiens | 1 | ALA4376897 | organism-based format | Scientific Literature | |
14. | ALA4381960 | F | Antitumor activity against human HepG2 cells xenografted in BALB/c nude mouse assessed as tumor growth suppression at 20 mg/kg, iv administered once every 3 days for 21 consecutive days and measured after 21 days by digital caliper method relative to control | Homo sapiens | 1 | ALA4376897 | organism-based format | Scientific Literature | |
15. | ALA4381961 | T | Toxicity in BALB/c nude mouse xenografted with human HepG2 cells assessed as effect on body weight at 10 to 20 mg/kg, iv administered once every 3 days for 21 consecutive days and measured after 21 days | Mus musculus | 1 | ALA4376897 | organism-based format | Scientific Literature | |
16. | ALA4381962 | B | Inhibition of STAT3 phosphorylation at Y705 residue in human SKOV3 cells by Western blot analysis | Homo sapiens | 1 | ALA4376897 | cell-based format | Scientific Literature | |
17. | ALA4381963 | B | Inhibition of STAT3 phosphorylation at S727 residue in human SKOV3 cells at 0.1 to 0.5 uM after 200 sec by Western blot analysis | Homo sapiens | 1 | ALA4376897 | cell-based format | Scientific Literature | |
18. | ALA4381964 | B | Inhibition of STAT1 phosphorylation in human SKOV3 cells at 0.1 to 0.5 uM by Western blot analysis | Homo sapiens | 1 | ALA4376897 | cell-based format | Scientific Literature | |
19. | ALA4381965 | B | Inhibition of STAT5 phosphorylation in human SKOV3 cells at 0.1 to 0.5 uM by Western blot analysis | Homo sapiens | 1 | ALA4376897 | cell-based format | Scientific Literature | |
20. | ALA4381966 | B | Inhibition of STAT1 activation (unknown origin) expressed in human SKOV3 cells cotransfected with pRL-CMV assessed as reduction in luciferase expression at 0.1 to 0.5 uM after 24 hrs by dual luciferase assay | Homo sapiens | 1 | ALA4376897 | cell-based format | Scientific Literature |