# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4400721 | Functional | Growth inhibition in human HeLa cells after 72 hrs by trypan blue dye-based assay | Homo sapiens | 21 | ALA4400511 | cell-based format | Scientific Literature | |
2. | ALA4400722 | Functional | Growth inhibition in human A431 cells after 72 hrs by trypan blue dye-based assay | Homo sapiens | 21 | ALA4400511 | cell-based format | Scientific Literature | |
3. | ALA4400723 | Functional | Growth inhibition in human MSTO-211H cells after 72 hrs by trypan blue dye-based assay | Homo sapiens | 21 | ALA4400511 | cell-based format | Scientific Literature | |
4. | ALA4400734 | Binding | Binding affinity to salmon DNA at compound to DNA ratio of 0.04 by linear flow dichroism analysis | Salmonidae | 12 | ALA4400511 | nucleic acid format | Scientific Literature | |
5. | ALA4400735 | Binding | Inhibition of recombinant human topoisomerase 2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 60 mins by ethidium bromide staining based agarose gel electrophoresis method | Homo sapiens | 20 | ALA4400511 | single protein format | Scientific Literature | |
6. | ALA4400736 | Binding | Inhibition of recombinant human topoisomerase 1 assessed as decrease in relaxation of supercoiled pBR322 DNA after 60 mins by ethidium bromide staining based agarose gel electrophoresis method | Homo sapiens | 20 | ALA4400511 | single protein format | Scientific Literature | |
7. | ALA4400738 | Binding | Poison activity at recombinant human topoisomerase-2 assessed as stabilization of covalent topo-2-DNA cleavage complex by measuring linear DNA formation at 10 uM using supercoiled pBR322 DNA as substrate after 60 mins by agarose gel electrophoresis method | Homo sapiens | 19 | ALA4400511 | single protein format | Scientific Literature | |
8. | ALA4400741 | Binding | Poison activity at recombinant human topoisomerase-1 assessed as stabilization of covalent topo-1-DNA cleavage complex by measuring nicked DNA formation at 0.5 to 50 uM using supercoiled pBR322 DNA as substrate after 60 mins by agarose gel electrophoresis method | Homo sapiens | 20 | ALA4400511 | single protein format | Scientific Literature |