| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4331522 | B | Inhibition of Plasmodium falciparum recombinant N-terminal His6-tagged DHODH (159-569 residues) expressed in Escherichia coli BL21(DE3) using DHO as substrate measured every min for 5 mins by DCPI dye-based photometric analysis | Plasmodium falciparum | 17 | assay format | Scientific Literature | ||
| 2. | ALA4331523 | B | Inhibition of human recombinant N-terminal GST-tagged DHODH (31 to 395 residues) expressed in Escherichia coli BL21(DE3) using DHO as substrate preincubated for 5 mins followed by substrate addition and measured for 5 mins by DCPI dye-based assay | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 3. | ALA4331524 | B | Selectivity ratio of IC50 for human recombinant DHODH to IC50 for Plasmodium falciparum recombinant DHODH | 17 | assay format | Scientific Literature | |||
| 4. | ALA4331525 | F | Anti-plasmodial activity against synchronized ring stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasitemia after 48 hrs by Sybr Green I dye-based flow cytometric analysis | Plasmodium falciparum | 18 | organism-based format | Scientific Literature | ||
| 5. | ALA4331526 | A | Cytotoxicity against African green monkey COS7 cells after 48 hrs by MTT assay | Chlorocebus aethiops | 18 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!