| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4481328 | B | Inhibition of full length His-tagged human DDX3X expressed in Escherichia coli assessed as reduction in DDX3X helicase activity using FAM-labeled double stranded RNA as substrate after 40 mins by FRET assay relative to control | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 2. | ALA4481334 | A | Cytotoxicity against human HuH7 cells after 3 days by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA4481337 | F | Antiviral activity against West Nile virus infected in human HuH7 cells incubated for 4 days by crystal violet staining based plaque reduction assay | West Nile virus | 10 | organism-based format | Scientific Literature | ||
| 4. | ALA4481340 | A | Apparent permeability of the compound by PAMPA | 7 | assay format | Scientific Literature | |||
| 5. | ALA4481341 | P | Aqueous solubility of the compound at 1 mg after 24 to 36 hrs by LC-MS/MS analysis | 7 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4481342 | A | Metabolic stability in human liver microsomes at 50 uM after 60 mins in presence of NADPH-generating system by LC-UV-MS analysis | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 7. | ALA4616145 | F | Antiviral activity against Dengue virus serotype 2 New Guinea C infected at 50 TCID50 in human HuH7 cells assessed as inhibition of viral replication and 72 hrs later re-infected pre-seeded HuH7 cells with viral supernatant collected from previous infected and measured after 72 hrs by immunodetection assay | dengue virus type 2 | 21 | organism-based format | Scientific Literature | ||
| 8. | ALA4616146 | A | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability by measuring ATP level measured after 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 9. | ALA4616148 | B | Inhibition of recombinant full length human His-tagged DDX3X expressed in Escherichia coli using dsRNA as substrate measured after 40 mins in presence of ATP by FRET assay | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 10. | ALA4616149 | F | Antiviral activity against Dengue virus serotype 2 New Guinea C infected at 100 TCID50 in human HuH7 cells assessed as reduction in number of NS3 positive cells at 0.1 to 20 uM measured up to 24 hrs by Alexa fluor 488 dye based confocal microscopy | dengue virus type 2 | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4616150 | F | Antiviral activity against Dengue virus serotype 2 New Guinea C infected at 100 TCID50 in human HuH7 cells assessed as reduction in number of NS5 positive cells at 0.1 to 20 uM measured up to 24 hrs by Alexa fluor 488 dye based confocal microscopy | dengue virus type 2 | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4616151 | F | Antiviral activity against Dengue virus serotype 2 New Guinea C infected at 100 TCID50 in human HuH7 cells assessed as cytopathic effect by measuring increase in viable cells at 0.1 to 20 uM measured up to 24 hrs by Alexa fluor 488 based confocal microscopy | dengue virus type 2 | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4616152 | F | Antiviral activity against Dengue virus serotype 2 New Guinea C infected at 100 TCID50 in human HuH7 cells assessed as reduction in number of dsRNA positive cells at 0.1 to 20 uM measured up to 24 hrs by Alexa fluor 488 dye based confocal microscopy | dengue virus type 2 | 1 | organism-based format | Scientific Literature |
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