# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4480708 | Functional | Antiproliferative activity against human procaspase-3 over-expressing U937 cells after 24 hrs by CCK-8 assay | Homo sapiens | 26 | ALA4480380 | cell-based format | Scientific Literature | |
2. | ALA4480709 | Functional | Antiproliferative activity against human MCF7 cells after 24 hrs by CCK-8 assay | Homo sapiens | 26 | ALA4480380 | cell-based format | Scientific Literature | |
3. | ALA4480710 | Functional | Selectivity ratio of IC50 for human MCF7 cells to IC50 for human procaspase-3 over-expressing U937 cells | Homo sapiens | 15 | ALA4480380 | assay format | Scientific Literature | |
4. | ALA4480711 | Functional | Induction of apoptosis in human U937 cells assessed as early apoptotic cells at 2.6 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 4.88%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
5. | ALA4480712 | Functional | Induction of apoptosis in human U937 cells assessed as late apoptotic cells at 2.6 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.27%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
6. | ALA4480713 | Functional | Induction of apoptosis in human U937 cells assessed as early apoptotic cells at 5.2 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 4.88%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
7. | ALA4480714 | Functional | Induction of apoptosis in human U937 cells assessed as late apoptotic cells at 5.2 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.27%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
8. | ALA4480719 | Functional | Induction of apoptosis in human U937 cells assessed as early apoptotic cells at 2.6 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 6.16%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
9. | ALA4480720 | Functional | Induction of apoptosis in human U937 cells assessed as late apoptotic cells at 2.6 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.89%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
10. | ALA4480721 | Functional | Induction of apoptosis in human U937 cells assessed as early apoptotic cells at 5.2 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 6.16%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
11. | ALA4480722 | Functional | Induction of apoptosis in human U937 cells assessed as late apoptotic cells at 5.2 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 3.89%) | Homo sapiens | 1 | ALA4480380 | cell-based format | Scientific Literature | |
12. | ALA4480727 | Functional | Induction of apoptosis in human U937 cells assessed as caspase-3 activity at 30 uM using Ac-DEVD-AFC as substrate preincubated for 16 hrs followed by substrate addition and measured after 60 mins by fluorescence assay (Rvb = 7+/- 1%) | Homo sapiens | 10 | ALA4480380 | cell-based format | Scientific Literature | |
13. | ALA4480728 | Binding | Activation of procaspase-3 (unknown origin) at 10 uM using Ac-DEVD-AFC as substrate preincubated for 4 hrs followed by substrate addition and measured after 5 mins by fluorescence assay relative to control | Homo sapiens | 3 | ALA4480380 | single protein format | Scientific Literature | |
14. | ALA4480729 | ADME | Toxicity in zebrafish AB embryos at 5 to 20 uM measured at 24 to 72 hrs post fertilization by stereo microscopic analysis | Danio rerio | 2 | ALA4480380 | assay format | Scientific Literature | |
15. | ALA4480731 | ADME | Toxicity in zebrafish AB embryos assessed as induction of mortality at 40 uM after 72 hrs post fertilization by stereo microscopic analysis | Danio rerio | 2 | ALA4480380 | assay format | Scientific Literature | |
16. | ALA4480732 | Functional | Induction of apoptosis in zebrafish AB embryos assessed as accumulation of dying cells in head at 40 to 60 uM after 24 hrs post fertilization by acridine orange staining-based fluorescence microscopic analysis | Danio rerio | 2 | ALA4480380 | organism-based format | Scientific Literature | |
17. | ALA4480733 | Functional | Induction of apoptosis in zebrafish AB embryos assessed as accumulation of dying cells in cranial neural crest at 40 to 60 uM after 24 hrs post fertilization by acridine orange staining-based fluorescence microscopic analysis | Danio rerio | 2 | ALA4480380 | organism-based format | Scientific Literature | |
18. | ALA4480734 | Functional | Induction of apoptosis in zebrafish AB embryos assessed as increase in bax mRNA expression at 40 to 60 uM after 24 hrs post fertilization by RT-PCR analysis | Danio rerio | 2 | ALA4480380 | organism-based format | Scientific Literature | |
19. | ALA4480735 | ADME | Half life in human liver microsomes in presence of NADPH by LC-MS analysis | Homo sapiens | 3 | ALA4480380 | microsome format | Scientific Literature | |
20. | ALA4480736 | ADME | Half life in rat liver microsomes in presence of NADPH by LC-MS analysis | Rattus norvegicus | 3 | ALA4480380 | microsome format | Scientific Literature |