| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4414743 | B | Inhibition of human 5-LO transfected in HEK293 cells coexpressing FLAP assessed as reduction in leukotriene formation at 1 uM using arachidonic acid as substrate preincubated for 5 mins followed by calcium ionophore A23187/arachidonic acid addition and measured after 15 mins by RP-HPLC analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4723722 | F | Growth inhibition of human KMM-1 cells after 48 hrs by PrestoBlue cell viability assay | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 3. | ALA4723723 | F | Growth inhibition of human JJN-3 cells after 48 hrs by PrestoBlue cell viability assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4723724 | F | Growth inhibition of human MM1.R cells after 48 hrs by PrestoBlue cell viability assay | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 5. | ALA4723725 | F | Growth inhibition of human KMM-1 cells at 10 uM after 48 hrs by PrestoBlue cell viability assay relative to control | Homo sapiens | 9 | tissue-based format | Scientific Literature | ||
| 6. | ALA4723726 | F | Potency index, ratio of lenalidomide IC50 to test compound IC50 for growth inhibition of human KMM-1 cells | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 7. | ALA4723728 | F | Induction of apoptosis in human KMM-1 cells assessed as apoptotic cells at 10 uM after 72 hrs by Annexin V/PropidiumIodide staining based flow cytometric analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4723729 | F | Induction of apoptosis in human MM1.R cells assessed as apoptotic cells at 10 uM after 72 hrs by Annexin V/PropidiumIodide staining based flow cytometric analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA4723737 | F | Down regulation of IKZF1 protein expression in human MM1.R cells at 5 to 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4723738 | F | Down regulation of IKZF3 protein expression in human MM1.R cells at 5 to 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4723739 | F | Down regulation of MYC protein expression in human MM1.R cells at 5 to 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4723740 | F | Down regulation of SP1 protein expression in human MM1.R cells at 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4723741 | F | Down regulation of SP1 protein expression in human JJN-3 cells at 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4723745 | F | Induction of apoptosis in human MM1.R cells assessed as increase in cleaved caspace-8 protein expression at 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4723747 | F | Down regulation of IRF4 protein expression in human JJN-3 cells at 10 to 100 uM after 48 hrs in presence of TMP by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4723748 | F | Down regulation of IKZF1 protein expression in human JJN-3 cells at 10 to 100 uM after 48 hrs in presence of TMP by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4723749 | F | Induction of apoptosis in human JJN-3 cells assessed as increase in cleaved caspace-8 protein expression at 10 to 50 uM after 48 hrs by Annexin V/Propidium Iodide flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4723750 | F | Induction of apoptosis in human MM1.R cells at 10 uM after 48 hrs by Annexin V/Propidium Iodide flow cytometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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