# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4414743 | Binding | Inhibition of human 5-LO transfected in HEK293 cells coexpressing FLAP assessed as reduction in leukotriene formation at 1 uM using arachidonic acid as substrate preincubated for 5 mins followed by calcium ionophore A23187/arachidonic acid addition and measured after 15 mins by RP-HPLC analysis | Homo sapiens | 8 | ALA4414547 | cell-based format | Scientific Literature | |
2. | ALA4723722 | Functional | Growth inhibition of human KMM-1 cells after 48 hrs by PrestoBlue cell viability assay | Homo sapiens | 4 | ALA4715865 | tissue-based format | Scientific Literature | |
3. | ALA4723723 | Functional | Growth inhibition of human JJN-3 cells after 48 hrs by PrestoBlue cell viability assay | Homo sapiens | 4 | ALA4715865 | cell-based format | Scientific Literature | |
4. | ALA4723724 | Functional | Growth inhibition of human MM1.R cells after 48 hrs by PrestoBlue cell viability assay | Homo sapiens | 4 | ALA4715865 | tissue-based format | Scientific Literature | |
5. | ALA4723725 | Functional | Growth inhibition of human KMM-1 cells at 10 uM after 48 hrs by PrestoBlue cell viability assay relative to control | Homo sapiens | 9 | ALA4715865 | tissue-based format | Scientific Literature | |
6. | ALA4723726 | Functional | Potency index, ratio of lenalidomide IC50 to test compound IC50 for growth inhibition of human KMM-1 cells | Homo sapiens | 2 | ALA4715865 | tissue-based format | Scientific Literature | |
7. | ALA4723728 | Functional | Induction of apoptosis in human KMM-1 cells assessed as apoptotic cells at 10 uM after 72 hrs by Annexin V/PropidiumIodide staining based flow cytometric analysis relative to control | Homo sapiens | 5 | ALA4715865 | cell-based format | Scientific Literature | |
8. | ALA4723729 | Functional | Induction of apoptosis in human MM1.R cells assessed as apoptotic cells at 10 uM after 72 hrs by Annexin V/PropidiumIodide staining based flow cytometric analysis relative to control | Homo sapiens | 5 | ALA4715865 | cell-based format | Scientific Literature | |
9. | ALA4723737 | Functional | Down regulation of IKZF1 protein expression in human MM1.R cells at 5 to 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA4715865 | cell-based format | Scientific Literature | |
10. | ALA4723738 | Functional | Down regulation of IKZF3 protein expression in human MM1.R cells at 5 to 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA4715865 | cell-based format | Scientific Literature | |
11. | ALA4723739 | Functional | Down regulation of MYC protein expression in human MM1.R cells at 5 to 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 1 | ALA4715865 | cell-based format | Scientific Literature | |
12. | ALA4723740 | Functional | Down regulation of SP1 protein expression in human MM1.R cells at 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 3 | ALA4715865 | cell-based format | Scientific Literature | |
13. | ALA4723741 | Functional | Down regulation of SP1 protein expression in human JJN-3 cells at 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 2 | ALA4715865 | cell-based format | Scientific Literature | |
14. | ALA4723745 | Functional | Induction of apoptosis in human MM1.R cells assessed as increase in cleaved caspace-8 protein expression at 10 uM after 48 hrs by immunoblotting analysis | Homo sapiens | 2 | ALA4715865 | cell-based format | Scientific Literature | |
15. | ALA4723747 | Functional | Down regulation of IRF4 protein expression in human JJN-3 cells at 10 to 100 uM after 48 hrs in presence of TMP by immunoblotting analysis | Homo sapiens | 1 | ALA4715865 | cell-based format | Scientific Literature | |
16. | ALA4723748 | Functional | Down regulation of IKZF1 protein expression in human JJN-3 cells at 10 to 100 uM after 48 hrs in presence of TMP by immunoblotting analysis | Homo sapiens | 1 | ALA4715865 | cell-based format | Scientific Literature | |
17. | ALA4723749 | Functional | Induction of apoptosis in human JJN-3 cells assessed as increase in cleaved caspace-8 protein expression at 10 to 50 uM after 48 hrs by Annexin V/Propidium Iodide flow cytometric analysis | Homo sapiens | 1 | ALA4715865 | cell-based format | Scientific Literature | |
18. | ALA4723750 | Functional | Induction of apoptosis in human MM1.R cells at 10 uM after 48 hrs by Annexin V/Propidium Iodide flow cytometric analysis | Homo sapiens | 2 | ALA4715865 | cell-based format | Scientific Literature |