| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4385774 | B | Inhibition of fluorescent labelled LBS2 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 60 mins followed by fluorescent labelled LBS2 addition and measured after 90 mins by fluorescence polarization assay | Human gammaherpesvirus 8 | 25 | ALA4385596 | assay format | Scientific Literature | |
| 2. | ALA4385777 | B | Inhibition of fluorescent labelled LBS1 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 60 mins followed by fluorescent labelled LBS2 addition and measured after 90 mins by fluorescence polarization assay | Human gammaherpesvirus 8 | 6 | ALA4385596 | assay format | Scientific Literature | |
| 3. | ALA4385778 | B | Inhibition of fluorescent labelled LBS3 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 60 mins followed by fluorescent labelled LBS2 addition and measured after 90 mins by fluorescence polarization assay | Human gammaherpesvirus 8 | 6 | ALA4385596 | assay format | Scientific Literature | |
| 4. | ALA4385779 | B | Inhibition of 5'-Dy682-labelled LBS1 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) at 500 uM preincubated for 1 hr followed by 5'-Dy682-labelled LBS1 DNA addition and measured after 30 mins by electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 6 | ALA4385596 | assay format | Scientific Literature | |
| 5. | ALA4385780 | B | Binding affinity to human herpesvirus human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) by microscale thermophoresis assay | Human gammaherpesvirus 8 | 1 | ALA4385596 | assay format | Scientific Literature | |
| 6. | ALA4385781 | B | Inhibition of 5'-Dy682-labelled LBS1/LBS2 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) at 500 uM preincubated for 1 hr followed by 5'-Dy682-labelled LBS1 DNA addition and measured after 30 mins by electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 6 | ALA4385596 | assay format | Scientific Literature | |
| 7. | ALA4385782 | B | Binding affinity to fluorescent labelled LBS2 DNA (unknown origin) by fluorescence polarization assay | Not specified | 45 | ALA4385596 | assay format | Scientific Literature | |
| 8. | ALA4385783 | B | Inhibition of 5'-Dy682-labelled LBS1 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 1 hr followed by 5'-Dy682-labelled LBS1 DNA addition and measured after 30 mins by electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 1 | ALA4385596 | assay format | Scientific Literature | |
| 9. | ALA4385784 | B | Inhibition of 5'-Dy682-labelled LBS1 DNA binding to GST-tagged LANA C-terminal domain (934 to 1162 residues) preincubated for 1 hr followed by 5'-Dy682-labelled LBS1 DNA addition and measured after 30 mins by electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 1 | ALA4385596 | assay format | Scientific Literature | |
| 10. | ALA4385785 | B | Binding affinity to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) at 1 mM by STD-NMR analysis | Human gammaherpesvirus 8 | 1 | ALA4385596 | assay format | Scientific Literature | |
| 11. | ALA4708322 | B | Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS1 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay | Human gammaherpesvirus 8 | 8 | ALA4706504 | assay format | Scientific Literature | |
| 12. | ALA4708323 | B | Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS2 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay | Human gammaherpesvirus 8 | 38 | ALA4706504 | assay format | Scientific Literature | |
| 13. | ALA4708324 | B | Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with 5'-Dy682-labeled viral DNA LBS1 probe at 500 uM preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 30 mins by Electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 44 | ALA4706504 | assay format | Scientific Literature | |
| 14. | ALA4708325 | B | Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS3 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay | Human gammaherpesvirus 8 | 8 | ALA4706504 | assay format | Scientific Literature | |
| 15. | ALA4708326 | B | Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with 5'-Dy682-labeled viral DNA LBS1 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 30 mins by Electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 5 | ALA4706504 | assay format | Scientific Literature | |
| 16. | ALA4708327 | B | Inhibition of Kaposi's sarcoma herpesvirus wild type LANA CTD (934 to 1162 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition of LANA interaction with 5'-Dy682-labeled viral DNA LBS1 probe at 250 uM preincubated with LANA CTD for 60 mins followed by addition of DNA probe and measured after 30 mins by Electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 8 | ALA4706504 | assay format | Scientific Literature | |
| 17. | ALA4708332 | B | Inhibition of Kaposi's sarcoma herpesvirus wild type LANA CTD (934 to 1162 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition of LANA interaction with 5'-Dy682-labeled viral DNA LBS1 probe preincubated with LANA CTD for 60 mins followed by addition of DNA probe and measured after 30 mins by Electrophoretic mobility shift assay | Human gammaherpesvirus 8 | 2 | ALA4706504 | assay format | Scientific Literature |
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