# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4394178 | Functional | Anti-inflammatory activity against carrageenan-induced albino rat paw edema model assessed as inhibition of microsomal PGE2 synthase expression in plasma at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge measured after 2 hrs by microplate reader based monoclonal sandwich ELISA assay | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature | |
2. | ALA4394179 | Binding | Inhibition of human recombinant COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition for 30 secs and measured after 1 hr by microplate reader based enzyme immunoassay | Homo sapiens | 15 | ALA4393660 | single protein format | Scientific Literature | |
3. | ALA4394180 | Binding | Inhibition of human recombinant COX-2 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition for 30 secs and measured after 1 hr by microplate reader based enzyme immunoassay | Homo sapiens | 15 | ALA4393660 | single protein format | Scientific Literature | |
4. | ALA4394181 | Functional | Anti-inflammatory activity against carrageenan-induced albino rat paw edema model assessed as inhibition of PGE2 production in plasma at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge measured after 2 hrs by microplate reader based enzyme immunoassay relative to control | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature | |
5. | ALA4394182 | Toxicity | Toxicity in carrageenan-induced albino rat paw edema model assessed as Inhibition of cytosolic PGE2 synthase expression in plasma at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge measured after 2 hrs by microplate reader based monoclonal sandwich ELISA assay | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature | |
6. | ALA4394183 | Binding | Selectivity index, ratio of IC50 for human recombinant COX1 to IC50 for human recombinant COX-2 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition for 30 secs and measured after 1 hr by microplate reader based enzyme immunoassay | Homo sapiens | 15 | ALA4393660 | assay format | Scientific Literature | |
7. | ALA4394184 | Functional | Anti-inflammatory activity against carrageenan-induced albino rat paw edema model assessed as inhibition of carrageenan-induced right hind paw edema at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge and measured immediately after carrageenan treatment by plethysmometer relative to control | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature | |
8. | ALA4394185 | Functional | Anti-inflammatory activity against carrageenan-induced albino rat paw edema model assessed as inhibition of carrageenan-induced right hind paw edema at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge and measured at 1 hr after carrageenan treatment by plethysmometer relative to control | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature | |
9. | ALA4394186 | Functional | Anti-inflammatory activity against carrageenan-induced albino rat paw edema model assessed as inhibition of carrageenan-induced right hind paw edema at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge and measured at 3 hrs after carrageenan treatment by plethysmometer relative to control | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature | |
10. | ALA4394187 | Functional | Anti-inflammatory activity against carrageenan-induced albino rat paw edema model assessed as inhibition of carrageenan-induced right hind paw edema at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge and measured at 2 hrs after carrageenan treatment by plethysmometer relative to control | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature | |
11. | ALA4394188 | Functional | Anti-inflammatory activity against carrageenan-induced albino rat paw edema model assessed as inhibition of carrageenan-induced right hind paw edema at 10 umol/kg, sc treated 1 hr prior to carrageenan challenge and measured at 6 hrs after carrageenan treatment by plethysmometer relative to control | Rattus norvegicus | 6 | ALA4393660 | organism-based format | Scientific Literature |