# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4362422 | Binding | Binding affinity to amyloid beta 1 to 42 (unknown origin) in PBS buffer at pH 7.4 assessed as increase in blue shift in maximum absorption at 0.2 uM by fluorescence based assay | Homo sapiens | 3 | ALA4359875 | single protein format | Scientific Literature | |
2. | ALA4362424 | Binding | Binding affinity to amyloid beta 1 to 42 (unknown origin) in PBS buffer at pH 7.4 assessed as binding constant by fluorescence based assay | Homo sapiens | 4 | ALA4359875 | single protein format | Scientific Literature | |
3. | ALA4362425 | Physicochemical | Photostability of compound | 4 | ALA4359875 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4362426 | ADME | Stability in mouse plasma assessed as remaining compound at 50 uM incubated for 30 to 60 mins by HPLC analysis | Mus musculus | 4 | ALA4359875 | cell-free format | Scientific Literature | |
5. | ALA4362427 | Toxicity | Dark toxicity against human SH-SY5Y cells assessed as reduction in cell viability at 50 uM incubated for 24 hrs by MTT assay | Homo sapiens | 4 | ALA4359875 | cell-based format | Scientific Literature |