# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4400721 | Functional | Growth inhibition in human HeLa cells after 72 hrs by trypan blue dye-based assay | Homo sapiens | 21 | ALA4400511 | cell-based format | Scientific Literature | |
2. | ALA4400722 | Functional | Growth inhibition in human A431 cells after 72 hrs by trypan blue dye-based assay | Homo sapiens | 21 | ALA4400511 | cell-based format | Scientific Literature | |
3. | ALA4400723 | Functional | Growth inhibition in human MSTO-211H cells after 72 hrs by trypan blue dye-based assay | Homo sapiens | 21 | ALA4400511 | cell-based format | Scientific Literature | |
4. | ALA4400724 | Functional | Induction of apoptosis in human HeLa cells assessed as early apoptotic cells at 20 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 5.6%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
5. | ALA4400725 | Functional | Induction of apoptosis in human HeLa cells assessed as late apoptotic cells at 20 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 2.2%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
6. | ALA4400726 | Functional | Induction of apoptosis in human HeLa cells assessed as necrotic cells at 20 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 0.7%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
7. | ALA4400727 | Functional | Induction of apoptosis in human HeLa cells assessed as viable cells at 20 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 91.6%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
8. | ALA4400728 | Functional | Induction of apoptosis in human HeLa cells assessed as early apoptotic cells at 80 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 5.6%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
9. | ALA4400729 | Functional | Induction of apoptosis in human HeLa cells assessed as late apoptotic cells at 80 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 2.2%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
10. | ALA4400730 | Functional | Induction of apoptosis in human HeLa cells assessed as necrotic cells at 80 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 0.7%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
11. | ALA4400731 | Functional | Induction of apoptosis in human HeLa cells assessed as viable cells at 80 uM after 18 hrs by Annexin-V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 91.6%) | Homo sapiens | 1 | ALA4400511 | cell-based format | Scientific Literature | |
12. | ALA4400732 | Binding | Binding affinity to salmon DNA at compound to DNA ratio of 0.02 to 0.04 by linear flow dichroism analysis | Salmonidae | 3 | ALA4400511 | nucleic acid format | Scientific Literature | |
13. | ALA4400735 | Binding | Inhibition of recombinant human topoisomerase 2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 60 mins by ethidium bromide staining based agarose gel electrophoresis method | Homo sapiens | 20 | ALA4400511 | single protein format | Scientific Literature | |
14. | ALA4400736 | Binding | Inhibition of recombinant human topoisomerase 1 assessed as decrease in relaxation of supercoiled pBR322 DNA after 60 mins by ethidium bromide staining based agarose gel electrophoresis method | Homo sapiens | 20 | ALA4400511 | single protein format | Scientific Literature | |
15. | ALA4400737 | Binding | Poison activity at recombinant human topoisomerase-2 assessed as stabilization of covalent topo-2-DNA cleavage complex by measuring linear DNA formation up to 50 uM using supercoiled pBR322 DNA as substrate after 60 mins by agarose gel electrophoresis method | Homo sapiens | 2 | ALA4400511 | single protein format | Scientific Literature | |
16. | ALA4400740 | Binding | Poison activity at recombinant human topoisomerase-1 assessed as stabilization of covalent topo-1-DNA cleavage complex by measuring nicked DNA formation using supercoiled pBR322 DNA as substrate after 60 mins by agarose gel electrophoresis method | Homo sapiens | 2 | ALA4400511 | single protein format | Scientific Literature | |
17. | ALA4400741 | Binding | Poison activity at recombinant human topoisomerase-1 assessed as stabilization of covalent topo-1-DNA cleavage complex by measuring nicked DNA formation at 0.5 to 50 uM using supercoiled pBR322 DNA as substrate after 60 mins by agarose gel electrophoresis method | Homo sapiens | 20 | ALA4400511 | single protein format | Scientific Literature |