# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345255 | B | Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins followed by substrate addition and measured after 3 hrs by PPiLight Inorganic Pyrophosphate assay kit method | Homo sapiens | 44 | assay format | Scientific Literature | ||
2. | ALA4345256 | F | Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
3. | ALA4345259 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
4. | ALA4345260 | A | Permeability across basolateral to apical side in human Caco2 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
5. | ALA4345265 | P | Kinetic solubility of compound at pH 2 | 2 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4345266 | P | Kinetic solubility of compound at pH 7 | 2 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4345270 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
8. | ALA4345271 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, po or 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
9. | ALA4345272 | A | Volume of distribution in Sprague-Dawley rat at 5 mg/kg, po or 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
10. | ALA4345273 | A | Half life in Sprague-Dawley rat at 5 mg/kg, po or 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
11. | ALA4345274 | B | Inhibition of human ERG | Homo sapiens | 1 | single protein format | Scientific Literature | ||
12. | ALA4345275 | A | Inhibition of CYP isoform (unknown origin) | Homo sapiens | 1 | protein format | Scientific Literature | ||
13. | ALA4345276 | B | Activation of human PXR at 15 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
14. | ALA4345277 | A | Cytotoxicity against human MT4 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
15. | ALA4345278 | B | Inhibition of MTH1 in human U2OS cells assessed as activation of p53 at 5 uM incubated for 4 and 24 hrs by Peggy sue Western blot assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
16. | ALA4345280 | F | Induction of DNA damage in human U2OS cells assessed as increase in gammaH2AX foci formation at 20 uM incubated for 72 hrs by immunostaining based confocal microscopy | Homo sapiens | 4 | cell-based format | Scientific Literature |