# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4305574 | B | Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay | Homo sapiens | 20 | ALA4304753 | single protein format | Scientific Literature | |
2. | ALA4305576 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 30 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 12 | ALA4304753 | cell-based format | Scientific Literature | |
3. | ALA4305577 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 10 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA4304753 | cell-based format | Scientific Literature | |
4. | ALA4305578 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 100 nM incubated for 4 hrs by Western blot analysis relative to control | Homo sapiens | 12 | ALA4304753 | cell-based format | Scientific Literature | |
5. | ALA4305580 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
6. | ALA4305581 | B | Protac activity at VHL/ERRbeta in human MDA-MB-231 cells assessed as induction of ERalpha degradation up to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
7. | ALA4305582 | B | Protac activity at VHL/ERRgamma in human MDA-MB-231 cells assessed as induction of ERalpha degradation up to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
8. | ALA4305583 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 0.5 to 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
9. | ALA4305584 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
10. | ALA4305585 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in MCAD protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
11. | ALA4305586 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in PDK4 protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
12. | ALA4305587 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as decrease in ATP5B protein expression level at 100 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
13. | ALA4305588 | B | Protac activity at VHL/ERRalpha in human MDA-MB-231 cells assessed as induction of ERalpha degradation at 3.0 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature | |
14. | ALA4305589 | B | Protac activity at VHL/ERRalpha in epoxomicin pre-treated human MDA-MB-231 cells assessed as induction of ERalpha degradation at 30 nM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4304753 | cell-based format | Scientific Literature |