# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4316844 | Binding | Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) self aggregation at 25 uM after 7 days by ThT-based fluorometric method relative to control | Homo sapiens | 12 | ALA4316585 | single protein format | Scientific Literature | |
2. | ALA4316845 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurodegeneration in human SH-SY5Y cells assessed as cell viability at 10 uM preincubated for 4 hrs followed by amyloid beta (1 to 42) addition and measured after 48 hrs by MTS assay (Rvb = 60.4%) | Homo sapiens | 10 | ALA4316585 | cell-based format | Scientific Literature | |
3. | ALA4316849 | Toxicity | Neurotoxicity against human SH-SY5Y cells assessed as cell viability at 10 to 40 uM after 24 hrs by MTT assay relative to control | Homo sapiens | 10 | ALA4316585 | cell-based format | Scientific Literature |