# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4339649 | Binding | Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 33 | ALA4339196 | cell-based format | Scientific Literature | |
2. | ALA4339656 | Binding | Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor measured after 2 hrs by liquid scintillation counting analysis | Rattus norvegicus | 27 | ALA4339196 | assay format | Scientific Literature | |
3. | ALA4339657 | ADME | Extraction ratio in human liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 25 | ALA4339196 | microsome format | Scientific Literature | |
4. | ALA4339658 | ADME | Inhibition of CYP1A2 in human liver microsomes | Homo sapiens | 19 | ALA4339196 | microsome format | Scientific Literature | |
5. | ALA4339659 | ADME | Inhibition of CYP2C19 in human liver microsomes | Homo sapiens | 22 | ALA4339196 | microsome format | Scientific Literature | |
6. | ALA4339660 | ADME | Inhibition of CYP2C8 in human liver microsomes | Homo sapiens | 14 | ALA4339196 | microsome format | Scientific Literature | |
7. | ALA4339661 | ADME | Inhibition of CYP2C9 in human liver microsomes | Homo sapiens | 25 | ALA4339196 | microsome format | Scientific Literature | |
8. | ALA4339662 | ADME | Inhibition of CYP2D6 in human liver microsomes | Homo sapiens | 14 | ALA4339196 | microsome format | Scientific Literature | |
9. | ALA4339663 | ADME | Inhibition of CYP3A4 in human liver microsomes | Homo sapiens | 14 | ALA4339196 | microsome format | Scientific Literature | |
10. | ALA4339664 | ADME | Extraction ratio in rat liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 25 | ALA4339196 | microsome format | Scientific Literature | |
11. | ALA4339665 | Binding | Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysis | Homo sapiens | 30 | ALA4339196 | cell-based format | Scientific Literature | |
12. | ALA4339666 | ADME | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK-MDR1 cells at 5 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 17 | ALA4339196 | cell-based format | Scientific Literature | |
13. | ALA4339667 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4339196 | organism-based format | Scientific Literature | |
14. | ALA4339668 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4339196 | organism-based format | Scientific Literature | |
15. | ALA4339669 | ADME | Cmax in Sprague-Dawley rat at 5 mg/kg, po administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4339196 | organism-based format | Scientific Literature | |
16. | ALA4339670 | ADME | AUC (infinity) in Sprague-Dawley rat at 5 mg/kg, po administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4339196 | organism-based format | Scientific Literature | |
17. | ALA4339671 | ADME | Tmax in Sprague-Dawley rat at 5 mg/kg, po administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4339196 | organism-based format | Scientific Literature | |
18. | ALA4339672 | ADME | Clearance in rat liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4339196 | microsome format | Scientific Literature | |
19. | ALA4339683 | ADME | Glutathione reactivity in human liver microsomes assessed as +GSH-2H+O2 adduct formation at 10 uM measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 5 | ALA4339196 | microsome format | Scientific Literature | |
20. | ALA4339684 | ADME | Glutathione reactivity in human liver microsomes assessed as +GSH-2H+O-CH2 adduct formation at 10 uM measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 5 | ALA4339196 | microsome format | Scientific Literature |