| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4396426 | B | Inhibition of rat brain cortex AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry | Rattus norvegicus | 15 | ALA4393722 | assay format | Scientific Literature | |
| 2. | ALA4396427 | B | Potency index, ratio of rivastigmine IC50 to compound IC50 for AChE in rat brain cortex using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry | Rattus norvegicus | 1 | ALA4393722 | assay format | Scientific Literature | |
| 3. | ALA4396428 | B | Metal chelating activity assessed as compound-Fe2+ complex formation at 25 uM incubated for 5 mins in presence of 25 uM FeSO4 by UV-visible spectrophotometry | 3 | ALA4393722 | assay format | Scientific Literature | ||
| 4. | ALA4396429 | B | Metal chelating activity assessed as compound-Cu2+ complex formation by measuring decrease in absorption with spectral shift to red end at 25 uM incubated for 5 mins in presence of 25 uM CuCl2 by UV-visible spectrophotometry | 3 | ALA4393722 | assay format | Scientific Literature | ||
| 5. | ALA4396431 | B | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM after 24 hrs by thioflavin-T fluorescence assay relative to control | Homo sapiens | 1 | ALA4393722 | single protein format | Scientific Literature | |
| 6. | ALA4396432 | B | Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-aggregation at 20 uM after 72 hrs by uranyl acetate staining based transmission electron microscopy | Homo sapiens | 3 | ALA4393722 | single protein format | Scientific Literature | |
| 7. | ALA4396433 | A | Drug metabolism assessed as mouse AChE-mediated hydrolysis by measuring 6-(1-(dimethylamino) ethyl) quinolin-8-ol incubated for 48 hrs by HPLC analysis | Mus musculus | 1 | ALA4393722 | single protein format | Scientific Literature | |
| 8. | ALA4396434 | A | Drug metabolism assessed as mouse AChE-mediated hydrolysis by measuring 6-(1-(dimethylamino) ethyl) quinolin-8-ol incubated for 12 hrs by HPLC analysis | Mus musculus | 1 | ALA4393722 | single protein format | Scientific Literature | |
| 9. | ALA4396435 | A | Stability of compound in human plasma measured up to 60 mins by HPLC analysis | Homo sapiens | 1 | ALA4393722 | cell-free format | Scientific Literature | |
| 10. | ALA4396436 | A | Stability of compound in human liver microsomes measured up to 60 mins by HPLC analysis | Homo sapiens | 1 | ALA4393722 | microsome format | Scientific Literature | |
| 11. | ALA4396437 | A | Stability of the compound in simulated gastric fluid measured up to 60 mins by HPLC analysis | 1 | ALA4393722 | assay format | Scientific Literature | ||
| 12. | ALA4396438 | A | Stability of the compound in simulated intestinal fluid measured up to 60 mins by HPLC analysis | 1 | ALA4393722 | assay format | Scientific Literature | ||
| 13. | ALA4396439 | A | Ratio of drug level in Sprague-Dawley rat brain to plasma at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature | |
| 14. | ALA4396440 | A | AUC (0 to t) in Sprague-Dawley rat plasma at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature | |
| 15. | ALA4396441 | A | AUC (0 to infinity) in Sprague-Dawley rat plasma at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature | |
| 16. | ALA4396442 | A | MRT in Sprague-Dawley rat plasma at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature | |
| 17. | ALA4396443 | A | Apparent clearance in Sprague-Dawley rat plasma at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature | |
| 18. | ALA4396444 | A | AUC (0 to t) in Sprague-Dawley rat blood dialysis at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature | |
| 19. | ALA4396445 | A | AUC (0 to infinity) in Sprague-Dawley rat blood dialysis at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature | |
| 20. | ALA4396446 | A | MRT in Sprague-Dawley rat blood dialysis at 25 mg/kg, iv by HPLC analysis | Rattus norvegicus | 1 | ALA4393722 | organism-based format | Scientific Literature |
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