# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420660 | B | Inhibition of human LATS1 kinase domain (589 to 1130 amino acids) incubated for 30 mins by HTRF assay | Homo sapiens | 244 | single protein format | Patent Bioactivity Data | ||
2. | ALA4420662 | B | Inhibition of human LATS2 kinase domain (553 to 1088 amino acids) incubated for 3 hrs in presence of FAM-KKLRRTLSVA-COOH by fluorescence detection based biochemical caliper assay | Homo sapiens | 244 | single protein format | Patent Bioactivity Data | ||
3. | ALA4420664 | B | Inhibition of LATS in human HaCaT cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay | Homo sapiens | 244 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4420665 | B | Inhibition of LATS in human HaCaT cells assessed as reduction in YAP nuclear translocation incubated for 24 hrs | Homo sapiens | 244 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4420666 | F | Induction of cell proliferation of C57BL/6 mouse hepatic progenitor cells assessed as conversion of hepatic progenitor cells into small organoids by measuring mean number of nuclei per organoid incubated for 4 days Hoechst-33342 staining based assay | Mus musculus | 3 | assay format | Patent Bioactivity Data | ||
6. | ALA4420671 | B | Inhibition of LATS in human JHH5 cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay | Homo sapiens | 284 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4420692 | B | Inhibition of LATS in human limbal epithelial cells with CRISPR/Cas9-mediated deletion of beta-2-microglobulin gene and HLA A/B/C genes assessed as induction of cell expansion to cell preparation without HLA class-I drivers of immune rejection (Rvb = 21%) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4420693 | A | Total drug level in cell pellets of human limbal stem cells by LC-MS analysis | Homo sapiens | 4 | assay format | Patent Bioactivity Data | ||
9. | ALA4420694 | A | Drug level in post wash cell pellets of human limbal stem cells by LC-MS analysis | Homo sapiens | 4 | assay format | Patent Bioactivity Data | ||
10. | ALA4420698 | B | Inhibition of LATS in human corneal endothelium cells assessed as induction of cell expansion by measuring ratio of expanded population of cells to population of seeded cells at 10 uM by Sytox orange dye based epifluorescence microscopy | Homo sapiens | 21 | assay format | Patent Bioactivity Data | ||
11. | ALA4420699 | B | Inhibition of LATS in human corneal endothelium cells assessed as induction of cell expansion by measuring cell density at 10 uM by Sytox orange dye based epifluorescence microscopy | Homo sapiens | 21 | assay format | Patent Bioactivity Data | ||
12. | ALA4420707 | B | Inhibition of LATS in human corneal endothelium cells assessed as reduction in endothelial to mesenchymal transition by measuring decrease in CD44 expression at 3 uM incubated for 2 weeks by FACS analysis | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
13. | ALA4420708 | B | Inhibition of LATS in human corneal endothelium cells assessed as reduction in endothelial to mesenchymal transition by measuring decrease in CD73 expression at 3 uM incubated for 2 weeks by FACS analysis | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
14. | ALA4420709 | B | Inhibition of LATS in human corneal endothelium cells assessed as reduction in endothelial to mesenchymal transition by measuring decrease in CD105 expression at 3 uM incubated for 2 weeks by FACS analysis | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
15. | ALA4420710 | B | Inhibition of LATS in human corneal endothelium cells assessed as reduction in endothelial to mesenchymal transition by measuring decrease in CD166 expression at 3 uM incubated for 2 weeks by FACS analysis | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
16. | ALA4420711 | A | Total drug level in cell pellets of human corneal endothelium cells by LC-MS analysis | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
17. | ALA4420712 | A | Drug level in cell pellets of human corneal endothelium cells by LC-MS analysis | Homo sapiens | 1 | assay format | Patent Bioactivity Data |