| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4417036 | A | Drug recovery in iv dosed mouse feces | Mus musculus | 9 | organism-based format | Scientific Literature | ||
| 2. | ALA4417038 | B | Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated for 15 mins followed by substrate addition and measured after 45 mins by AAO/horse radish peroxidase enzyme coupled assay | Homo sapiens | 26 | single protein format | Scientific Literature | ||
| 3. | ALA4417039 | B | Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 4. | ALA4417040 | A | Inhibition of N-terminal MetAP1 (unknown origin) | Homo sapiens | 26 | single protein format | Scientific Literature | ||
| 5. | ALA4417048 | P | Solubility of compound in PBS buffer | 10 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4417049 | A | Permeability of the compound from apical to basolateral side in human Caco2 cells | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA4417050 | A | Efflux ratio of permeability in human Caco2 cells | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 8. | ALA4417051 | A | Protein binding in mouse plasma assessed as unbound fraction | Mus musculus | 10 | cell-free format | Scientific Literature | ||
| 9. | ALA4417052 | A | Protein binding in human plasma assessed as unbound fraction | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
| 10. | ALA4417053 | A | AUC in mouse at 1 mg/kg, iv | Mus musculus | 9 | organism-based format | Scientific Literature | ||
| 11. | ALA4417054 | A | Ratio of unbound drug level in mouse to fIC50 for inhibition of MetAP2 in HUVEC cells | 9 | cell-based format | Scientific Literature | |||
| 12. | ALA4417055 | A | Plasma clearance in iv dosed mouse | Mus musculus | 9 | organism-based format | Scientific Literature | ||
| 13. | ALA4417056 | A | Volume of distribution at steady state in iv dosed mouse | Mus musculus | 9 | organism-based format | Scientific Literature | ||
| 14. | ALA4417057 | A | Half life in iv dosed mouse | Mus musculus | 9 | organism-based format | Scientific Literature |
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