# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4885534 | B | Biochemical assay (BCAT1) | Homo sapiens | 2 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
2. | ALA4885535 | B | Biochemical assay (BCAT2) | Homo sapiens | 2 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
3. | ALA4885538 | B | Cellular mechanistic assay – BCAA measurement (U-87-MG cells) | Homo sapiens | 2 | cell-based format | Donated Chemical Probes - SGC Frankfurt | ||
4. | ALA5217581 | B | Inhibition of N-terminal his-tagged human recombinant BCAT1 expressed in Escherichia coli BL21(DE3) cells using leucine and alpha-KG as substrate in presence of NADH by fluorescence assay | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
5. | ALA5217582 | B | Inhibition of human recombinant BCAT2 using leucine and alpha-KG as substrate in presence of NADH by fluorescence assay | Homo sapiens | 27 | single protein format | Scientific Literature | ||
6. | ALA5217583 | A | Apparent permeability of the compound from apical to basolateral side in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
7. | ALA5217584 | A | Efflux ratio of apparent permeability in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
8. | ALA5217585 | P | Dissociation constant, pKa of the compound | 16 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA5217592 | A | Metabolic stability in human liver microsomes assessed as blood clearance incubated upto 60 mins by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
10. | ALA5217593 | A | Metabolic stability in Wistar Han rat hepatocyte assessed as blood clearance at 1 uM incubated upto 90 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
11. | ALA5217594 | A | Metabolic stability in human liver microsomes assessed as maximal oral bioavailability incubated upto 60 mins by LC-MS/MS analysis | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
12. | ALA5217595 | A | Metabolic stability in Wistar Han rat hepatocyte assessed as maximal oral bioavailability incubated upto 90 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
13. | ALA5217596 | A | Apparent permeability of the compound from basolateral to apical side in human Caco-2 cells incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA5217600 | F | Upregulation of BCAA expression in human U-87 MG cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
15. | ALA5217608 | P | Lipophilicity, logD of compound at pH 7.5 | 1 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA5217609 | P | Aqueous solubility of compound in PBS buffer at pH 6.5 incubated for 24 hrs by HPLC-UV analysis | 1 | small-molecule physicochemical format | Scientific Literature |