# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4434274 | A | Cytotoxicity against human HepG2 cells at <50 uM incubated for 24 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4434275 | B | Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA4774163 | A | Half life in human liver microsomes measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
4. | ALA4774164 | A | Intrinsic clearance in human liver microsomes measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
5. | ALA4774165 | A | Half life in mouse liver microsomes measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
6. | ALA4774166 | A | Intrinsic clearance in mouse liver microsomes measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 7 | microsome format | Scientific Literature | ||
7. | ALA4774167 | A | Half life in rat liver microsomes measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
8. | ALA4774168 | A | Intrinsic clearance in rat liver microsomes measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 7 | microsome format | Scientific Literature | ||
9. | ALA4774169 | B | Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression at 1 uM incubated for 24 hrs prior to compound washout followed by compound addition and measured after 24 hrs by ELISA | Homo sapiens | 4 | cell-based format | Scientific Literature |