Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method relative to control
Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in absence of human serum by microbeta counting method relative to control
Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation measured after 60 mins in presence of 100% human serum by microbeta counting method
Inhibition of human recombinant full length acetylcholine esterase expressed in HEK293 cells at 10 uM using acetylcholine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by spectrophotometric analysis
Displacement of [3H]LTD4 from human full-length recombinant cysteinyl leukotriene type-2 receptor expressed in HEK293 cells at 10 uM measured after 60 mins by scintillation counting method relative to control