# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4379685 | Functional | Neuroprotective activity against Rotenone/Oligomycin A-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 0.1 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 3 | ALA4376837 | cell-based format | Scientific Literature | |
2. | ALA4379686 | Binding | Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ uptake at 10 uM by Fluo-4/AM dye based fluorescence microplate reader assay relative to control | Homo sapiens | 19 | ALA4376837 | cell-based format | Scientific Literature | |
3. | ALA4379687 | Binding | Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ uptake by Fluo-4/AM dye based fluorescence microplate reader assay | Homo sapiens | 19 | ALA4376837 | cell-based format | Scientific Literature | |
4. | ALA4379688 | Binding | Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method | Homo sapiens | 19 | ALA4376837 | cell-based format | Scientific Literature | |
5. | ALA4379689 | Functional | Antioxidant activity assessed as Trolox equivalents incubated for 15 mins by fluorescein based ORAC-FL assay | 19 | ALA4376837 | assay format | Scientific Literature | ||
6. | ALA4379690 | ADME | Permeability at 100 uM by PAMPA method | 19 | ALA4376837 | assay format | Scientific Literature | ||
7. | ALA4379691 | Binding | Inhibition of human recombinant AChE using acetylthiocholine iodide substrate by Ellman's protocol based assay | Homo sapiens | 16 | ALA4376837 | single protein format | Scientific Literature | |
8. | ALA4379692 | Binding | Inhibition of BuChE in human plasma using butyrylthiocholine iodide substrate by Ellman's protocol based assay | Homo sapiens | 3 | ALA4376837 | cell-free format | Scientific Literature | |
9. | ALA4379693 | Binding | Displacement of [3H]-Pyrilamine from human H1 receptor expressed in CHO-K1 cell membranes incubated for 60 mins by scintillation counting method | Homo sapiens | 2 | ALA4376837 | cell-based format | Scientific Literature | |
10. | ALA4379694 | Functional | Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calcium mobilization incubated for 16 hrs by aequorin-based functional assay | Homo sapiens | 3 | ALA4376837 | cell-based format | Scientific Literature | |
11. | ALA4379695 | Functional | Neuroprotective activity against Rotenone/Oligomycin A-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 0.3 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA4376837 | cell-based format | Scientific Literature | |
12. | ALA4379696 | Functional | Neuroprotective activity against Rotenone/Oligomycin A-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 1 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA4376837 | cell-based format | Scientific Literature | |
13. | ALA4379697 | Functional | Neuroprotective activity against Rotenone/Oligomycin A-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 3 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA4376837 | cell-based format | Scientific Literature | |
14. | ALA4379698 | Functional | Neuroprotective activity against okadaic acid-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 0.1 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 3 | ALA4376837 | cell-based format | Scientific Literature | |
15. | ALA4379699 | Functional | Neuroprotective activity against okadaic acid-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 0.3 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA4376837 | cell-based format | Scientific Literature | |
16. | ALA4379700 | Functional | Neuroprotective activity against okadaic acid-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 1 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA4376837 | cell-based format | Scientific Literature | |
17. | ALA4379701 | Functional | Neuroprotective activity against okadaic acid-induced cytotoxicity in human SH-SY5Y cells assessed as protection against cell death at 3 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | ALA4376837 | cell-based format | Scientific Literature | |
18. | ALA4379702 | Functional | Neuroprotective activity in mouse model of LPS-induced induced memory impairment assessed as improvement in discrimination index at 10 mg/kg, ip by novel object recognition test | Mus musculus | 2 | ALA4376837 | organism-based format | Scientific Literature | |
19. | ALA4379704 | ADME | Vasodilating activity in Wistar rat endothelium-denuded aortic rings preconstricted with 100 mM KCl assessed as vasorelaxation at 0.1 nM relative to control | Rattus norvegicus | 2 | ALA4376837 | tissue-based format | Scientific Literature | |
20. | ALA4379705 | ADME | Vasodilating activity in Wistar rat endothelium-denuded aortic rings preconstricted with 100 mM KCl assessed as vasorelaxation at 1 nM relative to control | Rattus norvegicus | 2 | ALA4376837 | tissue-based format | Scientific Literature |