| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4411820 | B | Substrate activity at recombinant human NQO1 assessed as ROS generation by measuring metabolic rate utilizing umol of NADPH per umol of enzyme at 10 uM preincubated for 3 mins followed by NADPH addition and measured at 2 secs interval for 5 mins | Homo sapiens | 33 | single protein format | Scientific Literature | ||
| 2. | ALA4411821 | B | Substrate activity at recombinant human NQO1 assessed as ratio of Kcat to Km by measuring umol of NADPH utilized per umol of enzyme at 10 uM preincubated for 3 mins followed by NADPH addition and measured at 2 secs interval for 5 mins by Michaelis-Menten plot analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 3. | ALA4411822 | F | Cytotoxicity against human A549/TR cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 4. | ALA4411823 | F | Cytotoxicity against human A549 cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 5. | ALA4411824 | A | Cytotoxicity against NQO1 deficient human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 6. | ALA4411825 | T | Selectivity ratio of IC50 for NQO1 deficient human L02 cells to IC50 for human A549/TR cells expressing NQO1 | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 7. | ALA4411826 | F | Cytotoxicity against human A549/VCR cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4411827 | F | Cytotoxicity against human MCF7 cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4411828 | F | Cytotoxicity against human MIAPaCa2 cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4411829 | A | Cytotoxicity against NQO1 deficient human NCI-H596 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4411830 | F | Cytotoxicity against human A549/TR cells expressing NQO1 assessed as reduction in cell viability in presence of DIC and measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4411831 | F | Cytotoxicity against human A549/TR cells expressing NQO1 assessed as reduction in cell viability in presence of NAC and measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4411832 | F | Selectivity ratio of IC50 for test compound cytotoxicity against human A549/TR cells expressing NQO1 in presence of NAC to IC50 for test compound cytotoxicity against human A549/TR cells expressing NQO1 in absence of NAC | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4411833 | B | Substrate activity at recombinant human NQO1 assessed as induction of ROS generation at 1 to 10 uM after 3 hrs by DCF-DA staining based fluorescence laser scanning confocal microscopic analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 15. | ALA4411834 | B | Substrate activity at recombinant human NQO1 assessed as induction of ROS generation at 1 to 10 uM treated post DIC addition and measured after 3 hrs by DCF-DA staining based fluorescence laser scanning confocal microscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4411835 | B | Substrate activity at recombinant human NQO1 assessed as induction of ROS generation at 1 to 10 uM treated post NAC addition and measured after 3 hrs by DCF-DA staining based fluorescence laser scanning confocal microscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4411836 | B | Substrate activity at recombinant human NQO1 assessed as ROS generation by measuring umol of cytochrome c utilized per umol of enzyme at 10 uM measured at 2 secs interval for 5 mins in presence of NADPH | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 18. | ALA4411837 | B | Substrate activity at recombinant human NQO1 assessed as ROS generation by measuring umol of cytochrome c utilized per umol of enzyme at 10 uM co-incubated with DIC measured at 2 secs interval for 5 mins in presence of NADPH | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA4411838 | B | Substrate activity at recombinant human NQO1 assessed as induction of DNA damage at 10 uM after 2 hrs by propidium iodide staining based laser scanning confocal microscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4411840 | B | Substrate activity at recombinant human NQO1 assessed as induction of DNA damage at 10 uM treated post DIC addition and measured after 2 hrs by propidium iodide staining based laser scanning confocal microscopic analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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