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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4434280 B Binding affinity to capsid protein in Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBV DNA replication incubated for 3 days followed by replacement of fresh medium containing compound and measured after 3 days by chemiluminescent assay Hepatitis B virus 21 cell-based format Scientific Literature 2. ALA4434281 A Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 3 days followed by replacement of fresh medium containing compound and measured after 3 days by cell titer glo-based luminescence assay Homo sapiens 21 cell-based format Scientific Literature 3. ALA4434282 A Half life in human hepatocytes Homo sapiens 7 cell-based format Scientific Literature 4. ALA4434283 A Oral bioavailability in CD1 mouse at 10 mg/kg Mus musculus 2 organism-based format Scientific Literature 5. ALA4434284 A Oral bioavailability in Mongrel dog at 3 mg/kg Canis lupus familiaris 2 organism-based format Scientific Literature 6. ALA4434285 A Half life in CD1 mouse at 10 mg/kg, po or 2 mg/kg, iv Mus musculus 2 organism-based format Scientific Literature 7. ALA4434287 A Half life in Mongrel dog at 3 mg/kg, po or 1 mg/kg, iv Canis lupus familiaris 2 organism-based format Scientific Literature 8. ALA4434288 A Clearance in CD1 mouse at 10 mg/kg, po or 2 mg/kg, iv Mus musculus 2 organism-based format Scientific Literature 9. ALA4434290 A Clearance in Mongrel dog at 3 mg/kg, po or 1 mg/kg, iv Canis lupus familiaris 2 organism-based format Scientific Literature 10. ALA4434291 A Volume of distribution at steady state in CD1 mouse at 10 mg/kg, po or 2 mg/kg, iv Mus musculus 2 organism-based format Scientific Literature 11. ALA4434293 A Volume of distribution at steady state in Mongrel dog at 3 mg/kg, po or 1 mg/kg, iv Canis lupus familiaris 2 organism-based format Scientific Literature 12. ALA4434294 A AUC in CD1 mouse plasma at 5 mg/kg Mus musculus 1 organism-based format Scientific Literature 13. ALA4434295 A AUC in CD1 mouse liver at 5 mg/kg Mus musculus 1 organism-based format Scientific Literature 14. ALA4434296 F Ratio of EC50 for antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells in presence of 40% normal human serum to EC50 for antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells in absence of 40% normal human serum Hepatitis B virus 3 organism-based format Scientific Literature 15. ALA4434297 P Lipophilicity, log P of the compound 3 small-molecule physicochemical format Scientific Literature 16. ALA4434298 A Substrate activity at OCT1 (unknown origin) at 10 uM Homo sapiens 1 single protein format Scientific Literature 17. ALA4434299 A Substrate activity at OCT2 (unknown origin) at 10 uM Homo sapiens 1 single protein format Scientific Literature 18. ALA4434300 A Substrate activity at OAT1 (unknown origin) at 10 uM Homo sapiens 1 single protein format Scientific Literature 19. ALA4434301 A Substrate activity at OAT3 (unknown origin) at 10 uM Homo sapiens 1 single protein format Scientific Literature 20. ALA4434302 A Substrate activity at OATP1B1 (unknown origin) at 10 uM Homo sapiens 1 single protein format Scientific Literature