# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4308446 | Binding | Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system at 10 uM preincubated with enzyme/ATP mixture for 20 mins followed by TK substrate-biotin addition followed by further incubation for 15 mins in presence of ATP by HTRF assay relative to control | Homo sapiens | 120 | ALA4304826 | assay format | Scientific Literature | |
2. | ALA4308447 | Binding | Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system at 1 uM preincubated with enzyme/ATP mixture for 20 mins followed by TK substrate-biotin addition followed by further incubation for 15 mins in presence of ATP by HTRF assay relative to control | Homo sapiens | 120 | ALA4304826 | assay format | Scientific Literature | |
3. | ALA4308448 | Binding | Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincubated with enzyme/ATP mixture for 20 mins followed by TK substrate-biotin addition followed by further incubation for 15 mins in presence of ATP by HTRF assay | Homo sapiens | 120 | ALA4304826 | assay format | Scientific Literature | |
4. | ALA4308449 | Binding | Inhibition of human full length TRKA expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assay | Homo sapiens | 113 | ALA4304826 | cell-based format | Scientific Literature | |
5. | ALA4308450 | Binding | Inhibition of human full length TRKB expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assay | Homo sapiens | 114 | ALA4304826 | cell-based format | Scientific Literature |