# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4324510 | Functional | Antiviral activity against Enterovirus A71 infected in human RD cells assessed as reduction in cytopathic effect incubated for 2 to 3 days by MTS assay | Enterovirus A71 | 20 | ALA4321853 | organism-based format | Scientific Literature | |
2. | ALA4324511 | ADME | Cytotoxicity against human RD cells assessed as reduction in cell viability incubated for 2 to 3 days by MTS assay | Homo sapiens | 20 | ALA4321853 | cell-based format | Scientific Literature | |
3. | ALA4324512 | Toxicity | Selectivity index, ratio of CC50 for human RD cells to EC50 for Enterovirus A71 infected in human RD cells | 14 | ALA4321853 | cell-based format | Scientific Literature | ||
4. | ALA4324513 | Functional | Antiviral activity against Human coxsackievirus B3 infected in human RD cells assessed as reduction in cytopathic effect incubated for 2 to 3 days by MTS assay | Coxsackievirus B3 | 11 | ALA4321853 | organism-based format | Scientific Literature | |
5. | ALA4324514 | ADME | Cytotoxicity against human RD cells infected with Human coxsackievirus B3 assessed as reduction in cell viability incubated for 2 to 3 days by MTS assay | Homo sapiens | 11 | ALA4321853 | cell-based format | Scientific Literature | |
6. | ALA4324515 | Functional | Antiviral activity against Human rhinovirus A2 infected in human RD cells assessed as reduction in cytopathic effect incubated for 2 to 3 days by MTS assay | rhinovirus A2 | 11 | ALA4321853 | organism-based format | Scientific Literature | |
7. | ALA4324516 | ADME | Cytotoxicity against human RD cells infected with Human rhinovirus A2 assessed as reduction in cell viability incubated for 2 to 3 days by MTS assay | Homo sapiens | 11 | ALA4321853 | cell-based format | Scientific Literature | |
8. | ALA4324517 | Functional | Antiviral activity against Human rhinovirus B14 infected in human RD cells assessed as reduction in cytopathic effect incubated for 2 to 3 days by MTS assay | rhinovirus B14 | 11 | ALA4321853 | organism-based format | Scientific Literature | |
9. | ALA4324518 | ADME | Cytotoxicity against human RD cells infected with Human rhinovirus B14 assessed as reduction in cell viability incubated for 2 to 3 days by MTS assay | Homo sapiens | 11 | ALA4321853 | cell-based format | Scientific Literature | |
10. | ALA4324519 | Binding | Corrector activity at CFTR F508del mutant (unknown origin) transfected in human HEK293 membrane cells assessed as increase in CFTR level at 3 uM incubated for 24 hrs by using pHTomato probe based fluorescence inverted microscopic analysis | Homo sapiens | 6 | ALA4321853 | cell-based format | Scientific Literature | |
11. | ALA4324520 | Physicochemical | Aqueous solubility of compound by LC-MS analysis | 2 | ALA4321853 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4324521 | ADME | Apparent permeability of compound by PAMPA assay | 2 | ALA4321853 | assay format | Scientific Literature | ||
13. | ALA4324522 | ADME | Membrane retention of compound by PAMPA assay | 2 | ALA4321853 | assay format | Scientific Literature | ||
14. | ALA4324523 | ADME | Metabolic stability in human liver microsomes assessed as compound remaining at 50 uM incubated for 1 hr by UV/LC-MS analysis | Homo sapiens | 2 | ALA4321853 | microsome format | Scientific Literature | |
15. | ALA4324524 | ADME | Stability in human plasma assessed as half life measured upto 24 hrs by UV/LC-MS analysis | Homo sapiens | 2 | ALA4321853 | cell-free format | Scientific Literature | |
16. | ALA4324525 | ADME | Binding affinity to human serum albumin assessed as dissociation constant incubated for 30 mins by spectrofluorimetry | Homo sapiens | 2 | ALA4321853 | single protein format | Scientific Literature | |
17. | ALA4324526 | ADME | Binding affinity to human serum albumin assessed as maximum binding at 0.1 to 500 uM incubated for 30 mins by spectrofluorimetry | Homo sapiens | 2 | ALA4321853 | single protein format | Scientific Literature | |
18. | ALA4324527 | Toxicity | Acute toxicity in C57BL/6 mouse assessed as effect on motor coordination upto 180 mg/kg, sc observed for 15 days | Mus musculus | 1 | ALA4321853 | organism-based format | Scientific Literature | |
19. | ALA4324528 | Toxicity | Acute toxicity in C57BL/6 mouse assessed as effect on behavior changes upto 180 mg/kg, sc observed for 15 days | Mus musculus | 1 | ALA4321853 | organism-based format | Scientific Literature | |
20. | ALA4324529 | Toxicity | Acute toxicity in C57BL/6 mouse assessed as body weight loss upto 180 mg/kg, sc observed for 15 days | Mus musculus | 1 | ALA4321853 | organism-based format | Scientific Literature |