# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4384517 | B | Inhibition of human AC1 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
2. | ALA4384518 | B | Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
3. | ALA4384519 | B | Inhibition of human AC8 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation at 30 uM preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
4. | ALA4384520 | B | Selectivity ratio of IC50 for human AC8 expressed in HEK293 cells to IC50 for human AC1 expressed in HEK293 cells | Homo sapiens | 65 | cell-based format | Scientific Literature | ||
5. | ALA4384523 | A | Cytotoxicity against HEK293 cells expressing human AC1 at 30 uM preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by CellTiter-Glo luminescent cell viability assay relative to control | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
6. | ALA4384524 | B | Inhibition of human AC2 expressed in HEK293 cells assessed as PMA-stimulated cAMP accumulation at 30 uM preincubated for 30 mins followed by PMA stimulation and measured after 1 hr by fluorescence assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
7. | ALA4384525 | B | Inhibition of human AC5 expressed in HEK293 cells assessed as forskolin-stimulated cAMP accumulation at 30 uM preincubated for 30 mins followed by forskolin stimulation and measured after 1 hr by fluorescence assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature |