| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4408439 | F | Antiproliferative activity against human NCI-H1703 cells expressing FASN assessed as growth inhibition at 25 uM after 72 hrs by MTS assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 2. | ALA4408440 | F | Antiproliferative activity against human NCI-H1703 cells expressing FASN assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA4408441 | U | Selectivity index, ratio of IC50 for human SAE cells lacking FASN expression to IC50 for human NCI-H1703 cells expressing FASN | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 4. | ALA4408442 | F | Antiproliferative activity against human NCI-H1299 cells expressing FASN assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA4408443 | U | Selectivity index, ratio of IC50 for human SAE cells lacking FASN expression to IC50 for human NCI-H1299 cells expressing FASN expression | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 6. | ALA4408444 | F | Antiproliferative activity against human NCI-H1650 cells expressing FASN assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA4408445 | U | Selectivity index, ratio of IC50 for human SAE cells lacking FASN expression to IC50 for human NCI-H1650 cells expressing FASN | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 8. | ALA4408446 | F | Antiproliferative activity against human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 9. | ALA4408447 | A | Cytotoxicity against human SAE cells lacking FASN expression assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 10. | ALA4408448 | F | Induction of apoptosis in human NCI-H1703 cells expressing FASN assessed as increase in late apoptotic cells at 5 uM after 72 hrs by Annexin-V FITC/PI staining-based flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4408449 | F | Induction of apoptosis in human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as increase in late apoptotic cells at 5 uM after 72 hrs by Annexin-V FITC/PI staining-based flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4408455 | B | Inhibition of full length human FASN transfected in HeLa cell lysates at 10 uM using acetyl Co-A/malonyl Co-A as substrate preincubated with enzyme for 2 hrs followed by substrate addition measured after 10 mins in presence of NADPH by microplate reader analysis | Homo sapiens | 4 | subcellular format | Scientific Literature | ||
| 13. | ALA4408456 | P | Kinetic solubility of the compound in universal buffer at pH 7.4 measured at 25 degC after 24 hrs by UV/Visible spectroscopic analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA4408457 | F | Antiproliferative activity against human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as cell viability at 2 uM after 72 hrs in presence of exogenous lipid concentrate by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4408458 | B | Inhibition of FASN in human NCI-H1703 cells expressing FASN assessed as disruption of AKT/FASN positive feedback loop by measuring decrease in FASN expression after 48 hrs by Western immunoblot assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4408459 | B | Inhibition of FASN in human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as disruption of AKT/FASN positive feedback loop by measuring decrease in FASN expression after 48 hrs by Western immunoblot assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4408460 | B | Inhibition of FASN in human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as disruption of AKT/FASN positive feedback loop by measuring decrease in FASN expression at 1 uM after 48 hrs by Western immunoblot based densitometric assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4408461 | B | Inhibition of FASN in human PC9 cells harboring FASN expression and EGFR delE746-A750 mutant assessed as disruption of AKT/FASN positive feedback loop by measuring decrease in FASN expression at 5 uM after 48 hrs by Western immunoblot based densitometric assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4408464 | B | Inhibition of FASN in human NCI-H1703 cells expressing FASN assessed as disruption of AKT/FASN positive feedback loop by measuring decrease in FASN expression at 1 uM after 48 hrs by Western immunoblot based densitometric assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4408465 | B | Inhibition of FASN in human NCI-H1703 cells expressing FASN assessed as disruption of AKT/FASN positive feedback loop by measuring decrease in FASN expression at 5 uM after 48 hrs by Western immunoblot based densitometric assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature |
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