# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4356730 | B | Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | Homo sapiens | 10 | ALA4354826 | assay format | Scientific Literature | |
2. | ALA4356733 | B | Protac activity at CRBN/STAT3 in human MOLM16 cells assessed as degradation of STAT3 incubated for 4 hrs by Western blot analysis | Homo sapiens | 25 | ALA4354826 | cell-based format | Scientific Literature | |
3. | ALA4356734 | B | Protac activity at CRBN/STAT3 in human MOLM16 cells assessed as degradation of STAT3 at 1 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
4. | ALA4356735 | B | Protac activity at CRBN/STAT3 in human MOLM16 cells assessed as degradation of phosphorylated STAT3 Y705 at 1 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
5. | ALA4356738 | B | Protac activity at CRBN/STAT3 in human SUDHL1 cells assessed as degradation of STAT3 upto 10 uM incubated for 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
6. | ALA4356739 | B | Protac activity at CRBN/STAT3 in human SUDHL1 cells assessed as degradation of phosphorylated STAT3 Y705 upto 10 uM incubated for 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
7. | ALA4356742 | B | Protac activity at CRBN/STAT3 in human SUDHL1 cells assessed as degradation of STAT3 incubated for 16 hrs by Western blot analysis | Homo sapiens | 25 | ALA4354826 | cell-based format | Scientific Literature | |
8. | ALA4356743 | F | Antiproliferative activity against human MOLM16 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay | Homo sapiens | 25 | ALA4354826 | cell-based format | Scientific Literature | |
9. | ALA4356744 | F | Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay | Homo sapiens | 25 | ALA4354826 | cell-based format | Scientific Literature | |
10. | ALA4356746 | B | Protac activity at CRBN/STAT3 in human MOLM16 cells assessed as degradation of STAT3 at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
11. | ALA4356753 | B | Protac activity at CRBN/STAT1 in human MOLM16 cells assessed as degradation of STAT1 at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
12. | ALA4356754 | B | Protac activity at CRBN/STAT2 in human MOLM16 cells assessed as degradation of STAT2 at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
13. | ALA4356755 | B | Protac activity at CRBN/STAT4 in human MOLM16 cells assessed as degradation of STAT4 at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
14. | ALA4356756 | B | Protac activity at CRBN/STAT5A in human MOLM16 cells assessed as degradation of STAT5A at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
15. | ALA4356757 | B | Protac activity at CRBN/STAT5B in human MOLM16 cells assessed as degradation of STAT5B at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
16. | ALA4356758 | B | Protac activity at CRBN/STAT6 in human MOLM16 cells assessed as degradation of STAT6 at 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
17. | ALA4356760 | B | Protac activity at CRBN/STAT3 in human SUDHL1 cells assessed as degradation of STAT3 at 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
18. | ALA4356767 | B | Protac activity at CRBN/STAT1 in human SUDHL1 cells assessed as degradation of STAT1 at 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
19. | ALA4356768 | B | Protac activity at CRBN/STAT2 in human SUDHL1 cells assessed as degradation of STAT2 at 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature | |
20. | ALA4356769 | B | Protac activity at CRBN/STAT4 in human SUDHL1 cells assessed as degradation of STAT4 at 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 2 | ALA4354826 | cell-based format | Scientific Literature |