# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4376379 | Binding | Transactivation of Gal4-fused human PPARgamma transfected in COS7 cells co-transfected with pGAL5-TK-pGL3 and pRennilla-CMV incubated for 39 hrs by dual luciferase reporter assay | Homo sapiens | 22 | ALA4373734 | cell-based format | Scientific Literature | |
2. | ALA4376380 | Binding | Transactivation of Gal4-fused human PPARgamma transfected in COS7 cells co-transfected with pGAL5-TK-pGL3 and pRennilla-CMV assessed as maximum intrinsic activation at 10 uM incubated for 39 hrs by dual luciferase reporter assay relative to pioglitazone | Homo sapiens | 21 | ALA4373734 | cell-based format | Scientific Literature | |
3. | ALA4376381 | Physicochemical | Solubility of compound in water at >20 uM | 10 | ALA4373734 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4376382 | Binding | Transactivation of Gal4-fused human PPARgamma transfected in COS7 cells co-transfected with pGAL5-TK-pGL3 and pRennilla-CMV assessed as maximum intrinsic activation at 20 uM incubated for 39 hrs by dual luciferase reporter assay | Homo sapiens | 11 | ALA4373734 | cell-based format | Scientific Literature | |
5. | ALA4376384 | ADME | Cytotoxicity against imatinib-resistant human K562-IMA[r] cells assessed as induction of cell death at 10 uM after 72 hrs by propidium iodide/Triton-X100 dye based FACS analysis relative to control | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
6. | ALA4376387 | Functional | Induction of sensitization to imatinib induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as cell death up to 2.5 uM measured after 72 hrs in presence of of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
7. | ALA4376388 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as gain in cell death rate at 5 uM measured after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis relative to imatinib-treated control | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
8. | ALA4376389 | ADME | Cytotoxicity against human HS5 cells assessed as cell death at 10 uM after 72 hrs by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 20 | ALA4373734 | cell-based format | Scientific Literature | |
9. | ALA4376390 | ADME | Cytotoxicity against human K562 cells assessed as cell death at 10 uM after 72 hrs by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 20 | ALA4373734 | cell-based format | Scientific Literature | |
10. | ALA4376391 | ADME | Cytotoxicity against African green monkey COS7 cells assessed as effect on cell metabolic activity at 20 uM after 72 hrs by MTT assay | Chlorocebus aethiops | 20 | ALA4373734 | cell-based format | Scientific Literature | |
11. | ALA4376394 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as induction of cell death at 10 uM after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis (Rvb = 15%) | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
12. | ALA4376395 | Functional | Induction of sensitization to imatinib-induced cytotoxicity in imatinib-resistant human K562-IMA[r] cells assessed as induction of cell death measured after 72 hrs in presence of 1 uM imatinib by propidium iodide/Triton-X100 dye based FACS analysis | Homo sapiens | 6 | ALA4373734 | cell-based format | Scientific Literature | |
13. | ALA4376396 | Physicochemical | Solubility of compound in DMSO at 10 uM by microscopic analysis | 20 | ALA4373734 | small-molecule physicochemical format | Scientific Literature |