# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4382905 | Binding | Inhibition of human N-terminal His6-tagged GGPPS expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting | Homo sapiens | 13 | ALA4382196 | assay format | Scientific Literature | |
2. | ALA4382906 | Binding | Inhibition of human FPPS using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting | Homo sapiens | 13 | ALA4382196 | single protein format | Scientific Literature | |
3. | ALA4382911 | Functional | Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay | Homo sapiens | 14 | ALA4382196 | cell-based format | Scientific Literature | |
4. | ALA4382912 | Binding | Inhibition of human N-terminal His6-tagged GGPPS Y246D mutant expressed in Escherichia coli BL21(DE3) using [14C]-IPP and FPP as substrates after 10 mins by scintillation counting | Homo sapiens | 14 | ALA4382196 | assay format | Scientific Literature | |
5. | ALA4382914 | ADME | Cytotoxicity against human NHBE cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent assay | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
6. | ALA4382915 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as viable cells at 1 uM after 72 hrs by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 87.3%) | Homo sapiens | 2 | ALA4382196 | cell-based format | Scientific Literature | |
7. | ALA4382916 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as early apoptotic cells at 1 uM after 72 hrs by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 3.31%) | Homo sapiens | 2 | ALA4382196 | cell-based format | Scientific Literature | |
8. | ALA4382917 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as late apoptotic cells at 1 uM after 72 hrs by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 5.80%) | Homo sapiens | 2 | ALA4382196 | cell-based format | Scientific Literature | |
9. | ALA4382918 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as necrotic cells at 1 uM after 72 hrs by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 3.60%) | Homo sapiens | 2 | ALA4382196 | cell-based format | Scientific Literature | |
10. | ALA4382919 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as viable cells at 1 uM after 72 hrs in presence GGOH by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 87.3%) | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
11. | ALA4382920 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as early apoptotic cells at 1 uM after 72 hrs in presence GGOH by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 3.31%) | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
12. | ALA4382921 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as late apoptotic cells at 1 uM after 72 hrs in presence GGOH by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 5.80%) | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
13. | ALA4382922 | Functional | Induction of apoptosis in human RPMI8226 cells assessed as necrotic cells at 1 uM after 72 hrs in presence GGOH by APC Annexin V/eFluor-780-viability double staining-based FACS analysis (Rvb = 3.60%) | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
14. | ALA4382931 | Functional | Antiproliferative activity against human KMS11 cells after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
15. | ALA4382932 | Functional | Antiproliferative activity against human OPM1 cells after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
16. | ALA4382933 | Functional | Antiproliferative activity against human JJN3R cells after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
17. | ALA4382934 | Functional | Antiproliferative activity against human KMS28PE cells after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature | |
18. | ALA4382935 | Functional | Antiproliferative activity against human NCI-ADR-RES cells after 72 hrs by celltiter-glo luminescent assay | Homo sapiens | 2 | ALA4382196 | cell-based format | Scientific Literature | |
19. | ALA4382936 | Functional | Antiproliferative activity against human MIAPaCa2 cells at 10 uM after 72 hrs by celltiter-glo luminescent assay | Homo sapiens | 2 | ALA4382196 | cell-based format | Scientific Literature | |
20. | ALA4382938 | Binding | Inhibition of GGPPS in human RPMI8226 cells assessed as reduction in Rap1A prenylation by Western blot analysis | Homo sapiens | 1 | ALA4382196 | cell-based format | Scientific Literature |