# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4306887 | Functional | Antileishmanial activity against Leishmania major promastigotes measured after 24 hrs by alamar blue staining based fluorescence assay | Leishmania major | 22 | ALA4304772 | organism-based format | Scientific Literature | |
2. | ALA4306888 | Functional | Antileishmanial activity against Leishmania major amastigotes measured after 72 hrs by resazurin dye based fluorescence assay | Leishmania major | 22 | ALA4304772 | organism-based format | Scientific Literature | |
3. | ALA4306889 | Functional | Potency index, ratio of miltefosine IC50 for Leishmania major amastigote form to compound IC50 for Leishmania major amastigote form | Leishmania major | 6 | ALA4304772 | organism-based format | Scientific Literature | |
4. | ALA4306890 | Binding | Inhibition of DHFR-TS/PTR1 in Leishmania major promastigote form assessed as parasite survival at 5.9 uM measured after 48 hrs relative to control | Leishmania major | 1 | ALA4304772 | assay format | Scientific Literature | |
5. | ALA4306891 | Binding | Inhibition of DHFR-TS/PTR1 in Leishmania major promastigote form assessed as parasite survival at 5.9 uM measured after 48 hrs in presence of 20 uM folic acid relative to control | Leishmania major | 1 | ALA4304772 | assay format | Scientific Literature | |
6. | ALA4306892 | Binding | Inhibition of DHFR-TS/PTR1 in Leishmania major promastigote form assessed as parasite survival at 5.9 uM measured after 48 hrs in presence of 100 uM folic acid relative to control | Leishmania major | 1 | ALA4304772 | assay format | Scientific Literature | |
7. | ALA4306893 | Functional | Antileishmanial activity against Leishmania major promastigote form assessed as parasite survival at 5.9 uM measured after 48 hrs in presence of 20 uM folinic acid relative to control | Leishmania major | 1 | ALA4304772 | organism-based format | Scientific Literature | |
8. | ALA4306894 | Functional | Antileishmanial activity against Leishmania major promastigote form assessed as parasite survival at 5.9 uM measured after 48 hrs in presence of 100 uM folinic acid relative to control | Leishmania major | 1 | ALA4304772 | organism-based format | Scientific Literature | |
9. | ALA4306901 | ADME | Cytotoxicity against African green monkey Vero cells after 72 hrs by crystal violet staining based assay | Chlorocebus sabaeus | 6 | ALA4304772 | cell-based format | Scientific Literature | |
10. | ALA4306902 | Toxicity | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for leishmania major promastigote | 6 | ALA4304772 | assay format | Scientific Literature | ||
11. | ALA4306904 | Binding | Reversible inhibition of DHFR-TS/PTR1 in Leishmania major promastigote form in presence of excess folic acid | Leishmania major | 22 | ALA4304772 | assay format | Scientific Literature |