# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4362357 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 1 uM measured after 48 hrs by MTT assay relative to control | Homo sapiens | 18 | ALA4359872 | cell-based format | Scientific Literature | |
2. | ALA4362358 | ADME | Cytotoxicity against human SH-SY5Y cells measured after 48 hrs by MTT assay | Homo sapiens | 18 | ALA4359872 | cell-based format | Scientific Literature | |
3. | ALA4362359 | Binding | Inhibition of recombinant mouse wild-type NAMPT expressed in bacterial expression system using PRPP as substrate in presence of mouse NMNAT-3 measured for 1 hr by fluorescence assay | Mus musculus | 18 | ALA4359872 | assay format | Scientific Literature | |
4. | ALA4362360 | ADME | Permeability across apical side to basolateral side in human Caco2 cells at 30 uM after 4 hrs by HPLC analysis | Homo sapiens | 5 | ALA4359872 | cell-based format | Scientific Literature | |
5. | ALA4362365 | Physicochemical | Kinetic aqueous solubility of the compound in 80:20 PBS/acetonitrile solution at 200 to 500 uM by HTS assay | 10 | ALA4359872 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4362369 | Binding | Inhibition of NAMPT in human SH-SY5Y cells assessed as reduction in NAD levels at 100 nM measured after 16 hrs by diaphorase and resazurin dye based fluorescence assay relative to control | Homo sapiens | 2 | ALA4359872 | cell-based format | Scientific Literature | |
7. | ALA4362399 | Unassigned | Selectivity ratio of EC50 for cytotoxicity against human SH-SY5Y cells to IC50 for recombinant mouse wild-type NAMPT expressed in bacterial expression system | 2 | ALA4359872 | cell-based format | Scientific Literature |