# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4380725 | B | Binding affinity to human wild-type partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by kinomescan assay | Homo sapiens | 5 | ALA4376874 | assay format | Scientific Literature | |
2. | ALA4380726 | B | Binding affinity to human wild-type partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system by kinomescan assay | Hofmanni bacterium | 5 | ALA4376874 | assay format | Scientific Literature | |
3. | ALA4380761 | B | Induction of EGFR exon 19 deletion mutant degradation in human HCC827 cells up to 100 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
4. | ALA4380762 | B | Induction of EGFR L858R degradation in human H3255 cells up to 100 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
5. | ALA4380763 | B | Induction of EGFR exon 19 deletion mutant degradation in human HCC827 cells assessed as reduction in EGFR autophosphorylation up to 100 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
6. | ALA4380764 | B | Induction of EGFR exon 19 deletion mutant degradation in human HCC827 cells assessed as reduction in AKT phosphorylation up to 100 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
7. | ALA4380765 | B | Induction of EGFR L858R degradation in human H3255 cells assessed as reduction in EGFR autophosphorylation up to 100 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
8. | ALA4380766 | B | Induction of EGFR L858R degradation in human H3255 cells assessed as reduction in ATK phosphorylation up to 100 nM treated 8 hrs post serum starvation measured after 16 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376874 | cell-based format | Scientific Literature | |
9. | ALA4380798 | F | Antiproliferative activity against human H3255 cells measured after 3 days by CCK8 assay | Homo sapiens | 6 | ALA4376874 | cell-based format | Scientific Literature |