# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4322426 | Binding | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cell membranes by radioligand competition assay | Homo sapiens | 22 | ALA4321802 | cell-based format | Scientific Literature | |
2. | ALA4322427 | Binding | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cell membranes by radioligand competition assay | Homo sapiens | 22 | ALA4321802 | cell-based format | Scientific Literature | |
3. | ALA4322428 | Binding | Displacement of [3H]HEMADO from human adenosine A3 receptor expressed in CHO cell membranes by radioligand competition assay | Homo sapiens | 22 | ALA4321802 | cell-based format | Scientific Literature | |
4. | ALA4322429 | Functional | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assay | Homo sapiens | 22 | ALA4321802 | cell-based format | Scientific Literature | |
5. | ALA4322430 | Functional | Antagonist activity at human adenosine A2A receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity by Glo-sensor cAMP assay | Homo sapiens | 5 | ALA4321802 | cell-based format | Scientific Literature | |
6. | ALA4322431 | Functional | Neuroprotective activity against 10 uM Oxaliplatin-induced neurotoxicity in Sprague-Dawley rat microglia assessed as cell viability at 10 uM incubated fro 24 hrs by MTT assay (Rvb = 33.2 +/- 1.3%) | Rattus norvegicus | 5 | ALA4321802 | cell-based format | Scientific Literature | |
7. | ALA4322432 | Functional | Neuroprotective activity against 30 uM Oxaliplatin-induced neurotoxicity in Sprague-Dawley rat microglia assessed as cell viability at 10 uM incubated fro 24 hrs by MTT assay (Rvb = 19.1 +/- 0.8%) | Rattus norvegicus | 5 | ALA4321802 | cell-based format | Scientific Literature | |
8. | ALA4322435 | Functional | Analgesic activity in CD1 albino mouse model of oxaliplatin-induced neuropathy hypersensitivity assessed as increase pain threshold at 10 to 30 mg/kg, po dosed from day 14 post oxaliplatin challenge and measured after 15 to 45 mins post dose by cold plate test | Mus musculus | 2 | ALA4321802 | organism-based format | Scientific Literature | |
9. | ALA4322440 | Binding | Displacement of [3H]NECA from rat adenosine A2A receptor expressed in CHO cell membranes by radioligand competition assay | Rattus norvegicus | 4 | ALA4321802 | cell-based format | Scientific Literature | |
10. | ALA4322441 | Physicochemical | Half life in 50 mM Tris buffer | 6 | ALA4321802 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4322442 | ADME | Half life in human plasma | Homo sapiens | 6 | ALA4321802 | cell-free format | Scientific Literature |